| Cat. No. |
Product Name |
Information |
| PC-26819 |
Myricoside
B4GALT3 inhibitor
|
Myricoside is a phenylethanoid triglycoside from Phlomis oppositiflora and small molecule β‑1,4‑galactosyltransferase III (B4GALT3) inhibitor. |
| PC-26815 |
Acarbose
alpha-glucosidase inhibitor
|
Acarbose (BAY g 5421) is an antihyperglycemic agent and orally active alpha-glucosidase (α-glucosidase) inhibitor with IC50 of 11 nM, potentiates the hypoglycemic effects of sulfonylureas or insulin. |
| PC-26812 |
BI-0115
LOX-1 inhibitor
|
BI-0115 is a selective small molecule inhibitor of lectin-like oxidized LDL receptor-1 (LOX-1) with IC50 of 5.4 uM, blocks cellular uptake of oxidized low-density lipoproteins (oxLDL). |
| PC-26802 |
CNT2198
DES1 inhibitor
|
CNT2198 is a potent, selective dihydroceramide desaturase 1 (DES1) inhibitor, lowers renal ceramides, increases dihydroceramides, and shifts complex sphingolipid saturation without evidence of off-target effects. |
| PC-26799 |
XM462
Dihydroceramide desaturase inhibitor
|
XM462 is a small molecule inhibitor of dihydroceramide desaturase (Des1) with IC50 of 8.2 uM and Ki of 2 uM, inhibits sphingolipid synthesis, triggers autophagy and reduces amyloid secretion by neurons. |
| PC-26798 |
Des 1 inhibitor GT11
Des1 inhibitor
|
Des 1 inhibitor GT11 ((1R,2S)-Deoxy-PR280) is a competitive inhibitor of dihydroceramide desaturase with Ki of 6 uM, induces Des1 inhibition in rat liver microsomes with IC50 of 20 uM. |
| PC-26797 |
PR280
Des1 inhibitor
|
PR280 is a potent small molecule inhibitor of dihydroceramide desaturase 1 (Des1) with IC50 of 700 nM. |
| PC-26781 |
C26-Ceramide
121459-09-4
|
C26 Ceramide is a lipid featuring two hydrophobic tails, one saturated and the other unsaturated, can be used in developing lipid nanoparticles or liposomes. |
| PC-26771 |
Kukoamine A
Trypanothione reductase inhibitor
|
Kukoamine A (KuA) is a potent and selective inhibitor of Crithidia fasciculata trypanothione reductase (TR) with Ki of 1.8 uM, with no significant inhibition on human glutathione reductase, possesses antioxidant, anti-inflammatory activities. |
| PC-26770 |
MEDS613
DHODH inhibitor
|
MEDS613 is a potent, selective hDHODH inhibitor with IC50 of 4.1 nM. |
| PC-26766 |
Acetyl-6-formylpterin
MAIT cell inhibitor, MR1 ligand/upregulator
|
Acetyl-6-formylpterin (Ac-6-FP, Acetyl-6-FP) is a small molecule ligand of MHC-related class I-like molecule MR1, markedly stabilizes MR1, potently up-regulates MR1 cell surface expression, and inhibits MAIT cell activation. |
| PC-26765 |
GAA-4OH
DEGS1 inhibitor
|
GAA-4OH is a potent and irreversible inhibitor of dihydroceramide desaturase-1 (DEGS1), covalently blocks the enzyme catalytic cavity, reduces ceramide-to-dihydroceramide ratios and improves steatosis, inflammation, and fibrosis in mouse model of MASLD. |
