| Cat. No. |
Product Name |
Information |
| PC-20107 |
RPE65-61
RPE65 inhibitor
|
RPE65-61 ((±)-RPE65-61) is a selective, non-retinoid and uncompetitive inhibitor of RPE65 (a key enzyme in the visual cycle), inhibits the retinol isomerase activity of RPE65 in vitro with IC50 of 80 nM. |
| PC-20064 |
GBT601
HbS polymerization inhibitor
|
GBT601 (Osivelotor, GBT021601) is an oral, small molecule, next-generation sickle hemoglobin (HbS) polymerization inhibitor, increases hemoglobin-oxygen (Hb-O2) affinity and stabilizes Hb in the oxy-hemoglobin (oxyHb) state, thereby inhibiting polymerization of HbS in RBCs. |
| PC-20062 |
SBL-105
DHODH inhibitor
|
SBL-105 (SBL105) is a potent, selective DHODH inhibitor with IC50 of 48.48 nM (rh DHODH). |
| PC-20061 |
Nizubaglustat
GCS inhibitor
|
Nizubaglustat (AZ-3102) is a potent, selective inhibitor of glucosylceramide synthase (GCS) with IC50 of 25 nM, inhibits acid glucosylceramidase (GBA1) and neutral glucosylceramidase (GBA2) with IC50 of 200 and 0.08 nM, respectively. |
| PC-20057 |
LY3473329
Lipoprotein (a) inhibitor
|
LY3473329 (Muvalaplin) is a potent, specific, multivalent, orally active disruptor/ inhibitor of lipoprotein(a) (Lp(a)) formation, binds to Kringle IV (KIV)8 domain selectively with a potency of 22 nM and inhibits the formation of Lp(a) particles in vitro with IC50 value of 0.09 nM. |
| PC-20052 |
KISS1-305
KISS1R agonist
|
KISS1-305 is a potent, selective KiSS1-derived peptide receptor (KISS1R) agonist with cellular IC50 of 8.94 nM. |
| PC-20048 |
(R)-SKBG-1
NONO ligand
|
(R)-SKBG-1 is a covalent small molecule ligand of RNA-binding protein NONO, engages NONO Cys145 and suppress an array of cancer-relevant genes and impair cancer cell proliferation. |
| PC-20028 |
Ederimotide
Wilms tumor protein 1 peptide
|
Ederimotide (WT1-A1) is a synthetic peptide derived from nonamer sequences of the Wilms tumor protein 1 (WT1), increases human T-cell responses and shows potential as cancer vaccine. |
| PC-20027 |
Dibutepinephrine
|
Dibutepinephrine is a sympathomimetic compound. |
| PC-20014 |
IGGi-11me
GIV-Gαi inhibitor
|
IGGi-11me is a specific, cell-active small molecule inhibitor of GIV-dependent G-protein cell signaling, binds to G-protein α-subunits, specifically disrupts their engagement with GIV/Girdin. |
| PC-20013 |
IGGi-11
GIV-Gαi inhibitor
|
IGGi-11 is a first-in-class small molecule inhibitor of non-canonical activation of heterotrimeric G-protein signaling, binds to G-protein α-subunits (Gαi, Gαi3 ITC Kd=4 uM), specifically disrupts their engagement with GIV/Girdin. |
| PC-20012 |
GCN2iB
GCN2 inhibitor
|
GCN2iB (GCN2 inhibitor) is a potent, selective and ATP-competitive GCN2 inhibitor with IC50 of 2.4 nM. |
