| Cat. No. |
Product Name |
Information |
| PC-26454 |
SMEI inhibitor 20e
SMEI inhibitor
|
SMEI inhibitor 20e is a small molecule inhibitor targeting SCN1A-associated severe myoclonic epilepsy of infancy (SMEI), shows potent antiseizure efficacy in zebrafish behavioral assays and significantly reduces locomotion-related seizure parameters, elevates 5-HT levels via TPH2 upregulation. |
| PC-26450 |
ACSS2-IN-1
ACSS2 inhibitor
|
ACSS2-IN-1 is a higly potent acetyl-CoA synthetase 2 (ACSS2) inhibitor with biochemical IC50 of 0.01 nM to <1 nM. |
| PC-26444 |
TQ416
PON2 inhibitor
|
TQ416 is a small molecule paraoxonase 2 (PON2) inhibitor, restores NF-κB transcriptional activity suppressed by N-(3-oxododecanoyl)-L-homoserine lactone (3OC12HSL, C12) with IC50 of 400 nM, rescues 3OC12HSL-induced cell death. |
| PC-26435 |
IDE activator Ia2
IDE activator
|
IDE activator Ia2 (IDE activator 2) is a potent, selective activator of insulin degrading enzyme (IDE), the hydrolysis of SP1 and FRET1 by IDE, significantly stimulates IDE proteolytic activity. |
| PC-26434 |
IDE activator Ia1
IDE activator
|
IDE activator Ia1 (IDE activator 1) is a potent, selective activator of insulin degrading enzyme (IDE), activates the hydrolysis of SP1 and FRET1 by IDE to ∼200% and ∼500%, activates the degradation of Aβ by ∼700%. |
| PC-26433 |
IDE inhibitor Ii1
IDE inhibitor
|
IDE inhibitor Ii1 (IDE inhibitor 1) is a potent, selective inhibitor of insulin degrading enzyme (IDE) with Ki of 1.7 nM. |
| PC-26432 |
BDM35899
IDE activator
|
BDM35899 is a small activator of insulin degrading enzyme (IDE) with pEC50 of 5.3, binds to polyanion-binding site of IDE, activates both Aβ and insulin hydrolysis by IDE, decreases glucose-stimulating insulin secretion in β-pancreatic cells. |
| PC-26431 |
BDM43124
IDE inhibitor
|
BDM43124 is the methyl ester precursor of BDM43079, which is a selective inhibitor of insulin degrading enzyme (IDE) with IC50 of 0.1 uM, inhibits the hydrolysis of amyloid-β1-40 by IDE in in SH-SY5Y cells. |
| PC-26430 |
BDM43079
IDE inhibitor
|
BDM43079 is a selective small molecule inhibitor of insulin degrading enzyme (IDE) with IC50 of 0.1 uM, selective of hIDE versus a panel of metalloproteases including hNEP. |
| PC-26428 |
BDM71230
IDE activator
|
BDM71230 is a potent, small molecule Insulin-Degrading Enzyme (IDE) activator with EC50 of 1.9 uM in glucose stimulated insulin secretion (GSIS) by pancreatic β-cells assay, 4.1-fold activation at 100 uM. |
| PC-26427 |
PKR1 agonist IS39
PKR1 agonist
|
PKR1 agonist IS39 is a selective, metabolically stable, non-peptide Prokineticin receptor-1 (PKR1, PROKR1) agonist, protects cardiomyocytes from doxorubicin-induced cytotoxicity. |
| PC-26426 |
APE1 inhibitor C10
APE1 inhibitor
|
APE1 inhibitor C10 (Refi-10) is a specific small molecule inhibitor of redox activity of APE1 with binding affinity (SPR Kd) of 189 nM, inhibits the redox function, but not the DNA repair function of APE1. |
