| Cat. No. |
Product Name |
Information |
| PC-72443 |
ONC212
GPR132 activator, ClpP activator
|
ONC212 (ONC-212) is a potent anti-cancer small molecule, activator of an orphan GPCR GPR132 and Gαq signaling, also is a potent activator of ClpP activator with EC50 of 131 nM. |
| PC-72440 |
AQX-435
SHIP1 activator
|
AQX-435 (AQX435) is a novel small molecule SHIP1 activator, inhibits anti-IgM-induced PI3K-mediated signaling, including induction of AKT phosphorylation and MYC expression, without effects on upstream SYK phosphorylation. |
| PC-72433 |
GRP-60367
RABV entry inhibitor
|
GRP-60367 (GRP60367) is a first-in-class, potent and specific, direct-acting rabies virus (RABV) inhibitor with EC50 of 2-52 nM on different host cell lines, inhibits entry of a subset of RABV strains. |
| PC-72408 |
SACLAC
Acid ceramidase inhibitor
|
SACLAC is an α-chloroamide ceramide analog that binds irreversibly to acid ceramidase (ASAH1), significantly reduces the viability of AML cells (EC50=3 uM) across 30 human AML cell lines. |
| PC-72399 |
Pannexin-1 inhibitor 15b
Pannexin-1 inhibitor
|
Panx-1 blocker 15b is a large-pore channel pannexin 1 (Panx1) inhibitor with IC50 of 0.8 uM. |
| PC-72398 |
NCATS-SM4487
GALK1 inhibitor
|
NCATS-SM4487 is a potent, small molecule inhibitor galactokinase (GALK1) with IC50 of 50 nM (hGALK1). |
| PC-72391 |
cis-Epoxysuccinic acid
SUCNR1 (GPR91) agonist
|
cis-Epoxysuccinic acid (cSE) is a synthetic non-metabolite GPR91 agonist with EC50 of 2.7 uM (cAMP levels reducion). |
| PC-72383 |
SRI-37330
TXNIP inhibitor
|
SRI-37330 (SRI 37330) is an orally available small molecule that regulates TXNIP expression, inhibits endogenous TXNIP mRNA expression (IC50=0.64 uM, INS-1 cells qRT-PCR assays). |
| PC-72381 |
HKB99
PGAM1 inhibitor
|
HKB99 (PGAM1 allosteric inhibitor HKB99) is a novel potent, cellularly active PGAM1 (Phosphoglycerate mutase 1) allosteric inhibitor, HKB99 is noncompetitive with the substrate 3-PG with IC50 of 0.85 uM in in vitro enzyme assays. |
| PC-72380 |
SUCNR1 inhibitor 20
SUCNR1 (GPR91) antagonist
|
SUCNR1 inhibitor 20 is a potent, selective inhibitor (antagonist) of GPCR SUCNR1 (succinate receptor 1/GPR91) with IC50 of 88 nM. |
| PC-72374 |
NF-56-EJ40
SUCNR1 (GPR91) antagonist
|
NF-56-EJ40 is a highly potent, human-selective antagonist of SUCNR1 (GPR91) with IC50 of 25 nM and Ki of 33 nM. |
| PC-72370 |
Ophiobolin A
Calmodulin inhibitor
|
Ophiobolin A (OphA) is a potent, covalent CaM inhibitor, with broad toxicity against plants, microbes, and cancer cells, OphA also is a K-Ras4B but not an H-Ras selective inhibitor. |
