ELOVL6 inhibitor 37 | ELOVL6 inhibitor | Probechem Biochemicals

Chemical Structure : ELOVL6 inhibitor 37

CAS No.: 1067647-43-1

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ELOVL6 inhibitor 37 (ELOVL6-IN-2)

货号: PC-20305Not For Human Use, Lab Use Only.

ELOVL6 inhibitor 37 (ELOVL6-IN-2) is a potent, selective inhibitor of elongase of long-chain fatty acids family 6 (ELOVL6) with IC50 of 8.9 and 31 nM for human and mouse ELOVL6, respectively.

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10 mg	￥980	In stock
25 mg	￥1680	In stock
50 mg	￥2780	In stock
100 mg		Get quote

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生物&药学活性

ELOVL6 inhibitor 37 (ELOVL6-IN-2) is a potent, selective inhibitor of elongase of long-chain fatty acids family 6 (ELOVL6) with IC50 of 8.9 and 31 nM for human and mouse ELOVL6, respectively.
ELOVL6 inhibitor 37 weakly inhibits hELOVL3 (IC50=337 nM), and does not inhibit hELOVL1, hELOVL2 and hELOVL5 (IC50>10 uM).
ELOVL6 inhibitor 37 (0.1, 0.3, and 1 mg/kg, 0.5% methylcellulose, oral) potently and dose-proportionally suppressed the elongation index in the liver in mice.

物理化学性质&存储条件

分子量	579.50
分子式	C28H23F6N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,5-dimethyl-3-(5-methyl-3-oxo-2-(4-(trifluoromethoxy)phenyl)-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione

参考文献

1. Toshiyuki Takahashi, et al. J Med Chem. 2009 May 28;52(10):3142-5.

ELOVL6 inhibitor 37 (ELOVL6-IN-2)

生物&药学活性

物理化学性质&存储条件

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ELOVL6 inhibitor 37 (ELOVL6-IN-2)

生物&药学活性

物理化学性质&存储条件

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