| Cat. No. |
Product Name |
Information |
| PC-25314 |
UNI110
CAS 2648334-60-3
|
UNI110 is a potent small molecule inhibitor of mismatch repair (MMR)-deficient cancer cells, selectively kills MutSa deficient cells with IC50 of 25.05 µM in HEC59 cells and 56.57 µM in HEC59-2 cells. |
| PC-25307 |
SyntOFF
Syntenin inhibitor
|
SyntOFF is a specific small molecule inhibitor of syntenin with IC50 of 37 uM in HTRF assays, targets the PDZ2 domain of syntenin. |
| PC-25283 |
KG022
hairpin RNAs binder
|
KG022 is a fluoroquinolone derivative, binds specifically to the bulge-out region of hairpin RNAs, binds to RNA-C and RNA-G stronger than RNA-A and RNA-U based on the exchange rates. |
| PC-25281 |
KI-DX-014
DDX21 inhibitor
|
KI-DX-014 is a specific small-molecule compound capable of inhibiting the interaction of DDX21 with RNA with IC50 of 3.31 uM, directly binds to DDX21-C-terminal domain (HC+CTD) with Kd of 15.9 uM, allosterically attenuates DDX21 ATPase activity. |
| PC-25280 |
PTC-775
MAPT splicing modulator
|
PTC-775 is a potent splicing modulator compound (SMC) that correct microtubule-associated protein tau (MAPT) splicing with EC2x value of 4.9 nM in MAPT minigene assay in HEK293T cells (3R MAPT), promotes MAPT exon 10 exclusion, increasing 3R MAPT transcript and protein levels. |
| PC-25279 |
PTC-553
MAPT splicing modulator
|
PTC-553 is a potent splicing modulator compound (SMC) with EC2x value of 12.7 nM in MAPT minigene assay in HEK293T cells (3R MAPT), promotes MAPT exon 10 exclusion, increasing 3R MAPT transcript and protein levels. |
| PC-25278 |
PTC-700
MAPT splicing modulator
|
PTC-700 is a potent splicing modulator compound (SMC) with EC2x value of 20.9 nM in MAPT minigene assay in HEK293T cells (3R MAPT), promotes MAPT exon 10 exclusion, increasing 3R MAPT transcript and protein levels. |
| PC-25277 |
PTC-003
MAPT splicing modulator
|
PTC-003 is a potent splicing modulator compound (SMC) that correct microtubule-associated protein tau (MAPT) splicing with EC2x value of 5.2 nM in MAPT minigene assay in HEK293T cells (3R MAPT), promotes MAPT exon 10 exclusion, increasing 3R MAPT transcript and protein levels. |
| PC-25275 |
Cycloleucine
MAT2A inhibitor
|
Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation, is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro, also inhibits MAT2A, Cycloleucine is an antagonist of NMDA receptor associated glycine receptor. |
| PC-25274 |
AGI-24512
MAT2A inhibitor
|
AGI-24512 is a highly potent, cell-active methionine adenosyltransferase 2α (MAT2A) inhibitor with enzymatic IC50 of 8 nM. |
| PC-25267 |
Ac5GlutolNAc
RENBP inhibitor
|
Ac5GlutolNAc is a specific small molecule inhibitor of GlcNAc 2-epimerase (RENBP), selectively enhances the labeling efficiency of tetraacetyl-N-azidoacetylmannosamine (AAM) in antigen-presenting cells (APCs), but not non-APCs. |
| PC-25260 |
IPR-3242
uPAR-uPA inhibitor
|
IPR-3242 is a small molecule inhibitor of the uPAR·uPA protein-protein interaction, inhibits the uPAR·uPAATF interaction with IC50 of 8.6 uM. |
