| Cat. No. |
Product Name |
Information |
| PC-27319 |
G2A antagonist 65
GPR132 antagonist
|
G2A antagonist 65 is a potent, selective G protein coupled receptor 132 (GPR132 or G2A) antagonist with IC50 of 0.69 uM, prevents the 9-HODE-mediated sensitization of capsaicin-induced TRPV1 responses in primary sensory neurons. |
| PC-27318 |
G2A antagonist 31
GPR132 antagonist
|
G2A antagonist 31 is a potent, selective G protein coupled receptor 132 (GPR132 or G2A) antagonist with IC50 of 0.33 uM. |
| PC-27317 |
Lysophosphatidylcholines
9008-30-4
|
Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL), induces cell injury, the production of IL-1β and apoptosis, shows proactive effect on sepsis. |
| PC-27301 |
PHB1 inhibitor TD6
Prohibitin 1 inhibitor
|
PHB1 inhibitor TD6 is a highly potent and selective small-molecule inhibitor of Prohibitin 1 (PHB1), exerts potent anti-tumor activities against CRC, effectively suppresses tumor growth and dissemination by disrupting mitochondrial energy metabolism. |
| PC-27300 |
Fluorizoline
Prohibitin binder
|
Fluorizoline is a synthetic molecule that induces apoptosis by selectively targeting prohibitins, directly binds to prohibitin 1 and 2 (PHB1 and PHB2). |
| PC-27294 |
LRPPRC inhibitor 3o
LRPPRC inhibitor
|
LRPPRC inhibitor 3o (LRPPRC-IN-1) is a potent small molecule inhibitor of Leucine-rich pentatricopeptide repeat containing (LRPPRC) with IC50 of <5 uM (92% inhibition at 6.25 uM), induces robust LRPPRC degradation. |
| PC-27293 |
FKA-9i
LRPPRC-YBX1-RPN1 inhibitor
|
FKA-9i is a potent broad-spectrum anticancer agent, directly binds to leucine-rich PPR motif-containing protein (LRPPRC), Y-box binding protein 1 (YBX1), and ribophorin I (RPN1) with 7.387 μM, 26.82 μM, and 16.52 μM, respectively, reducing their interactions and stability. |
| PC-27289 |
RUN-89
NRF1 activator
|
RUN-89 is a potent, specific activator of transcription factor nuclear factor erythroid 2-related factor 1 (encoded by NFE2L1, NRF1) with EC50 of 3.1 uM. |
| PC-27287 |
Vosoritide
C-type natriuretic peptide analog, NPR2 agonist
|
Vosoritide (BMN-111) is a biologic analogue of C-type natriuretic peptide (CNP) and a potent stimulator of endochondral ossification, acts to restore chondrogenesis through its binding to natriuretic peptide receptor B (NPR-B, NPR2), resulting in the inhibition of downstream signalling pathways of the overactive FGFR3 gene. |
| PC-27278 |
Catestatin TFA
Catecholamine release inhibitor
|
Catestatin TFA is a potent catecholamine release inhibitory peptide with IC50 of 0.2-0.3 uM, acting as a nicotinic cholinergic antagonist, inhibits nicotinic cholinergic-stimulated catecholamine secretion, signal transduction, and desensitization. |
| PC-27277 |
Catestatin
Catecholamine release inhibitor
|
Catestatin is a potent catecholamine release inhibitory peptide with IC50 of 0.2-0.3 uM, acting as a nicotinic cholinergic antagonist, inhibits nicotinic cholinergic-stimulated catecholamine secretion, signal transduction, and desensitization. |
| PC-27270 |
XL20
TDP-43 inhibitor
|
XL20 is a brain-penetrant small molecule targeting the TDP-43 conserved α-helical region spanning residues 320-340 (conserved region, CR) to suppress neurotoxicity, binds to full-length TDP-43 and CR peptide with SPR KD of 10.4 uM and 7.84 uM. |
