PRD125 | ACAT2 inhibitor | Probechem Biochemicals

Chemical Structure : PRD125

加入收藏

PRD125 (PRD 125, PRD-125)

货号: PC-60714Not For Human Use, Lab Use Only.

PRD125 is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2, ACAT2) with IC50 of 11.8 nM, >6,000-fold selectivity over ACAT1.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

PRD125 is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2, ACAT2) with IC50 of 11.8 nM, >6,000-fold selectivity over ACAT1.
PRD125 markedly reduces hepatic cholesteryl ester accumulation and improves liver function in lysosomal acid lipase-deficient mice.
PRD125 improves both atherosclerosis and fatty liver progression in cholesterol diet-fed rabbits, shows more potent in vivo efficacy than atorvastatin.

物理化学性质&存储条件

分子量	688.777
分子式	C41H40N2O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,11-O-o-methylbenzylidene-7-O-p-cyanobenzoyl-1,7,11-trideacetylpyripyropene A

参考文献

1. Lopez AM, et al. J Pharmacol Exp Ther. 2015 Nov;355(2):159-67.

2. Ohshiro T, et al. J Pharmacol Exp Ther. 2015 Nov;355(2):299-307.

3. Ohshiro T, et al. Arterioscler Thromb Vasc Biol. 2011 May;31(5):1108-15.

4. Ohtawa M, et al. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3798-801.

PRD125 (PRD 125, PRD-125)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

PRD125 (PRD 125, PRD-125)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.