NGI-1 | OST inhibitor | Probechem Biochemicals

Chemical Structure : NGI-1

CAS No.: 790702-57-7

加入收藏

NGI-1 (ML414, NGI1)

货号: PC-60959Not For Human Use, Lab Use Only.

NGI-1 (ML414) is a potent, cell-permeable oligosaccharyltransferase (OST) inhibitor with IC50 of 1.1 uM.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

NGI-1 (ML414) is a potent, cell-permeable oligosaccharyltransferase (OST) inhibitor with IC50 of 1.1 uM.
NGI-1 (ML414) blocks cell-surface localization and signaling of the epidermal growth factor receptor (EGFR) glycoprotein in NSCLC cells.
NGI-1 (ML414) causes cell-cycle arrest accompanied by induction of p21, autofluorescence, and cell morphology changes, all hallmarks of senescence.
NGI-1 (ML414) reduces the production of both OST products (free glycans and N-glycans).
NGI-1 (ML414) is a small molecule chemical probe with N-linked glycosylation inhibitory activity.

物理化学性质&存储条件

分子量	394.508
分子式	C17H22N4O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(N,N-dimethylsulfamoyl)-N-(5-methylthiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide

参考文献

1. Puschnik AS, et al. Cell Rep. 2017 Dec 12;21(11):3032-3039.

2. Lopez-Sambrooks C, et al. Nat Chem Biol. 2016 Dec;12(12):1023-1030.

3. Baro M, et al. Clin Cancer Res. 2018 Jul 2. pii: clincanres.0792.2018. doi: 10.1158/1078-0432.CCR-18-0792.

NGI-1 (ML414, NGI1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

NGI-1 (ML414, NGI1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.