ADDA5 | Cytochrome c oxidase inhibitor | Probechem Biochemicals

Chemical Structure : ADDA 5

CAS No.: 473268-46-1

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ADDA 5 (ADDA 5 hydrochloride, ADDA-5)

货号: PC-60849Not For Human Use, Lab Use Only.

ADDA 5 is a specific, non-competitive, small molecule cytochrome c oxidase (CcO or complex IV) inhibitor with IC50 of 18.93 uM (CcO from human glioma).

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25 mg	￥2380	In stock
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生物&药学活性

ADDA 5 is a specific, non-competitive, small molecule cytochrome c oxidase (CcO or complex IV) inhibitor with IC50 of 18.93 uM (CcO from human glioma).
ADDA 5 displays no inhibition of other mitochondrial complexes or other relevant enzymes (LDH, XO, SOD, GPs etc.).
ADDA 5 dose-dependently inhibited the proliferation of chemosensitive and chemoresistant glioma cells but does not display toxicity against non-cancer cells.
ADDA 5 also blcoks cell proliferation and neurosphere formation in cultures of glioma stem cells, inhibits tumor growth in flank xenograft mouse models.

物理化学性质&存储条件

分子量	406.007
分子式	C24H36ClNO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[2-(1-adamantyl)ethoxy]-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-propanol hydrochloride

参考文献

1. Oliva CR, et al. J Biol Chem. 2016 Nov 11;291(46):24188-24199.

ADDA 5 (ADDA 5 hydrochloride, ADDA-5)

生物&药学活性

物理化学性质&存储条件

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ADDA 5 (ADDA 5 hydrochloride, ADDA-5)

生物&药学活性

物理化学性质&存储条件

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