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首页-小分子抑制剂&激动剂-Others-Other Targets-LX2931
LX2931

Chemical Structure : LX2931

CAS No.: 948840-25-3

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LX2931 (LX-2931)

货号: PC-60694Not For Human Use, Lab Use Only.

LX-2931 (LX2931) is a potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor.

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5 mg ￥3580 In stock
10 mg ￥5480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LX2931 is a potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor.
LX2931 dose-dependently decreases circulating lymphocyte numbers in multiple species and shows a therapeutic effect in rodent models of rheumatoid arthritis (RA).
LX2931 also increases S1P levels in F508del CFTR mutant mice, reduces MUC5AC and proinflammatory cytokine levels toward normal values.

物理化学性质&存储条件

分子量 245.235
分子式 C9H15N3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime

参考文献

1. Bagdanoff JT, et al. J Med Chem. 2010 Dec 23;53(24):8650-62.

2. Veltman M, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L1000-L1014.

3. Finney CA, et al. Mol Med. 2011;17(7-8):717-25.

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