| Cat. No. |
Product Name |
Information |
| PC-25146 |
BI033
BACH1 inhibitor
|
BI033 is a selective small-molecule BTB and CNC homology 1 (BACH1) inhibitor, specifically binds to BACH1 WT with Kd of 9.0 uM, significantly upregulates HO-1 mRNA and protein expression. |
| PC-25137 |
GI-Y1
GSDMD inhibitor
|
GSDMD inhibitor Y1 (GI-Y1) is a selective gasdermin D (GSDMD) inhibitor, binds to GSDMD with SPR KD of 7.69 uM, shows cardioprotective effects. |
| PC-25105 |
DEL-S1
SLIT2/ROBO1 inhibitor
|
DEL-S1 is a first-in-class small molecule that binds to SLIT2 and disrupts its interaction with ROBO1 with IC50 of 68.8 uM in TR-FRET assays. |
| PC-25037 |
BMN 349
Z α1-antitrypsin polymerisation inhibitor
|
BMN 349 (Crovozalpon, BMN349) is a specific small molecule inhibitor of Z mutant alpha-1 antitrypsin (Z-AAT) polymerization that preferentially binds Z-AAT and blocks polymerization. |
| PC-25013 |
TREM2 agonist C1
TREM2 agonist
|
TREM2 agonist C1 is a structural analog of VG-3927 and small molecule agonist of triggering receptor expressed on myeloid cells 2 (TREM2) with KD of 71.36 uM in MST assays. |
| PC-25011 |
YT-II-100
CPSF3 inhibitor
|
YT-II-100 is a novel small molecule inhibitor of Cleavage and Polyadenylation Specific Factor 3 (CPSF3), increases the global abundance of R-loops. |
| PC-24839 |
NGI-186
Oligosaccharyltransferase inhibitor
|
NGI-186 is a potent, small molecule inhibitor of oligosaccharyltransferase (OST) with IC50 of 0.06 uM. |
| PC-24838 |
NGI-190
Oligosaccharyltransferase inhibitor
|
NGI-190 is a potent, small molecule inhibitor of oligosaccharyltransferase (OST) with IC50 of 0.59 uM. |
| PC-24837 |
NGI-189
Oligosaccharyltransferase inhibitor
|
NGI-189 is a potent, small molecule inhibitor of oligosaccharyltransferase (OST) with IC50 of 0.09 uM. |
| PC-24792 |
VG-3927
TREM2 agonist
|
VG-3927 (I-192) is a highly potent, selective and brain penetrant triggering receptor expressed on myeloid cells 2 (TREM2) agonist. |
| PC-24788 |
SANA
Thermogenesis inducer
|
SANA is a nitroalkene derivative of salicylate, and a first-in-class activator of creatine-dependent energy expenditure and thermogenesis, induces creatine-dependent thermogenesis and promotes weight loss. |
| PC-24750 |
SNT-5382
LOXL2 inhibitor
|
SNT-5382 is a potent, selective and irreversible LOXL2 inhibitor with IC50 of 10 nM, exhibits rapid, time-dependent LOXL2 inhibition and competitively binds to the active site of LOXL2. |
