| Cat. No. |
Product Name |
Information |
| PC-24788 |
SANA
Thermogenesis inducer
|
SANA is a nitroalkene derivative of salicylate, and a first-in-class activator of creatine-dependent energy expenditure and thermogenesis, induces creatine-dependent thermogenesis and promotes weight loss. |
| PC-24750 |
SNT-5382
LOXL2 inhibitor
|
SNT-5382 is a potent, selective and irreversible LOXL2 inhibitor with IC50 of 10 nM, exhibits rapid, time-dependent LOXL2 inhibition and competitively binds to the active site of LOXL2. |
| PC-24748 |
PXS-6302 hydrochloride
pan-LOX inhibitor
|
PXS-6302 hydrochloride (PXS6302) is a potent, irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 3.7 uM and 3.4/0.4/1.5/0.3 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively. |
| PC-24721 |
Cavolin-1 ligand WL47
Caveolin-1 inhibitor
|
Cavolin-1 ligand WL47 (WL47 TFA) is a peptide, high-affinity, selective disrupter / inhibitor of caveolin-1 (CAV) oligomerization with ITC KD of 23 nM, 7500-fold improved affinity compared to its T20 parent ligand. |
| PC-24685 |
BCX-3607
TF/FVIIa inhibitor
|
BCX-3607 is a potent, selective and orally active tissue factor/factor VIIa (TF-FVIIa) inhibitor with IC50 of 4 nM. |
| PC-24661 |
Core Circadian Modulator
BMAL1 ligand
|
Core Circadian Modulator (CCM) is specific small molecule BMAL1 ligand, targets the cavity in the PASB domain of BMAL1 with ITC Kd of 1.99 uM, modulates BMAL1-CLOCK target gene expressions. |
| PC-24650 |
Cucurbitacin B
IGF2BP1 inhibitor
|
Cucurbitacin B (CuB) is a potent but toxic anticancer natural product, an irreversible covalent inhibitor of IGF2BP1 and forms a covalent bond with cysteine 253 of the IGF2BP1 KH 1-2 domain (KD=66.8 nM). |
| PC-24626 |
RJG-2036
PTGR2 inhibitor
|
RJG-2036 is a potent, selective, covalent prostaglandin reductase 2 (PTGR2) inhibitor with IC50 of 100 nM (human PTGR2), covalently ligands the noncatalytic Y100 and Y265 residues located in the substrate binding pocket. |
| PC-24621 |
Fis1 inhibitor SP11
Fis1 inhibitor
|
SP11 is a potent inhibitor of activated Fis1 (mitochondrial fission protein 1), covalently binds specifically to Cys41 of activated Fis1, inhibits CPM fluorescence of Thr34Asp Fis1 with IC50 of 9.4 uM. |
| PC-24616 |
ORIC-533
CD73 inhibitor
|
ORIC-533 is a potent, selective, AMP-competitive and orally bioavailable ectonucleotidase CD73 inhibitor. |
| PC-24596 |
SALL4 inhibitor SH6
SALL4 degrader
|
SALL4 inhibitor SH6 is a small molecule inhibitor of transcription factor SALL4 ZFC4 domain, selectively targets SALL4-expressing cancer cells (EC50=0.5 uM, SNU398 cells), degrades SALL4 protein through the CUL4A/CRBN pathway. |
| PC-24547 |
Fascin inhibitor G2
Fascin inhibitor
|
Fascin inhibitor G2 is a small molecule inhibitor of Fascin (FSCN1), inhibits the actin-bundling function of fascin with IC50 of 5-8 uM, blocks tumour invasion and metastatic colonization. |
