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首页-小分子抑制剂&激动剂-Others-Other Targets-Kisspeptin 234
Kisspeptin 234

Chemical Structure : Kisspeptin 234

CAS No.: 1848962-29-7

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Kisspeptin 234 (Peptide 234, P234)

货号: PC-21174Not For Human Use, Lab Use Only.

Kisspeptin 234 (Peptide 234, P234) is a potent kisspeptin receptor (KISS1, GPR54) antagonist antagonist with binding IC50 of 2.7 nM in competition with 125I-kisspeptin-10, blocks the stimulatory effects of kisspeptin on hypothalamus-pituitary-gonadal (HPG) axis.

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10 mg ￥3580 In stock
25 mg ￥5880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Kisspeptin 234 (Peptide 234, P234) is a potent kisspeptin receptor (KISS1, GPR54) antagonist antagonist with binding IC50 of 2.7 nM in competition with 125I-kisspeptin-10, blocks the stimulatory effects of kisspeptin on hypothalamus-pituitary-gonadal (HPG) axis.
Peptide P234 potently inhibits 10 nM kisspeptin-10 stimulation of IP by 93%, with an IC50 of 7 nM and has no intrinsic IP stimulation.
Peptide 234 (1 nM) antagonizes kisspeptin-10 excitation of GnRH neurons.
Peptide 234 inhibits pulsatile GnRH release in pubertal female rhesus monkeys.
Peptide 234 inhibits kisspeptin-10 stimulated LH in intact male rats and the increase in LH after castration.

物理化学性质&存储条件

分子量 1409.43
分子式 C65H79F3N18O15
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Ac-Ala-Asn-Trp-Asn-Gly-Phe-Gly-Trp-Arg-Phe-NH2 TFA salt

参考文献

1. Fariba Mahmoudi, et al. Int J Endocrinol Metab. 2014 Jan 5;12(1):e12554.

2. Antonia K Roseweir, et al. J Neurosci. 2009 Mar 25;29(12):3920-9.

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