NP-G2-044 | Fascin-1 inhibitor | Probechem Biochemicals

Chemical Structure : NP-G2-044

CAS No.: 1807454-59-6

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NP-G2-044 (Fascin inhibitor)

货号: PC-21070Not For Human Use, Lab Use Only.

NP‐G2‐044 is a small molecule inhibitor of actin-bundling protein Fascin-1 (Fscn1), inhibits fascin-mediated actin bundling with IC50 of 0.2 uM.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2680	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

NP‐G2‐044 is a small molecule inhibitor of actin-bundling protein Fascin-1 (Fscn1), inhibits fascin-mediated actin bundling with IC50 of 0.2 uM.
Fascin (E391A mutant) (from the actin‐binding site 1) is insensitive to the inhibition by NP‐G2‐044.
NP‐G2‐044 engages the target fascin and blocks filopodial formation in cells, decreases filopodial formation resulting in decreased lamellipodial formation.
NP‐G2‐044 inhibits the migration of MDA‐MB‐231 tumor cells with IC50 of ~10 uM.
NP‐G2‐044 (intraperitoneally and daily at 100 mg/kg) inhibits tumor metastasis on breast tumor metastasis in mouse models.

物理化学性质&存储条件

分子量	399.37
分子式	C21H16F3N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Methyl-N-(1-(4-(trifluoromethyl)benzyl)-1H-indazol-3-yl)furan-3-carboxamide

参考文献

1. Shaoqin Han, et al. Mol Oncol. 2016 Aug;10(7):966-80.

NP-G2-044 (Fascin inhibitor)

生物&药学活性

物理化学性质&存储条件

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NP-G2-044 (Fascin inhibitor)

生物&药学活性

物理化学性质&存储条件

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