DSHN | NR0B2 agonist | Probechem Biochemicals

Chemical Structure : DSHN

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DSHN (NR0B2 agonist DSHN)

货号: PC-21100Not For Human Use, Lab Use Only.

DSHN is a small molecule activator of small heterodimer partner (SHP, NR0B2), functions as a transcriptional activator of SHP, inhibits HCC metastasis via SHP-mediated repression of Ccl2 signaling.

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生物&药学活性

DSHN is a small molecule activator of small heterodimer partner (SHP, NR0B2), functions as a transcriptional activator of SHP, inhibits HCC metastasis via SHP-mediated repression of Ccl2 signaling.
DSHN markedly reactivates Shp expression in both mouse (Nmuli, Hepa-1) and human (MHCC97H) hepatic cells in which Shp expression is lost.
DSHN activates Shp promoter luciferase reporter and augments the transactivation of several known Shp activators dose-dependently, including live receptor homolog 1 (LRH-1), hepatocyte nuclear factor 4α (HNF4α), and retinoid X receptor/retinoic acid receptor α (RXR/RARα).
DSHN also increases SHP protein half-life, prevents SHP protein ubiquitination and degradation.
DSHN is a potent activator of SHP through both transcriptional and post-transcriptional regulation.
DSHN (50 uM) inhibits CCl2-mediated HCC cell invasion and migration in Huh7 cells.

物理化学性质&存储条件

分子量	323.36
分子式	C15H17NO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(diethylsulfamoyl)-3-hydroxynaphthalene-2-carboxylic acid

参考文献

1. Yang Z, et al. Mol Cancer Ther. 2016 Oct;15(10):2294-2301.

DSHN (NR0B2 agonist DSHN)

生物&药学活性

物理化学性质&存储条件

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DSHN (NR0B2 agonist DSHN)

生物&药学活性

物理化学性质&存储条件

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