| Cat. No. |
Product Name |
Information |
| PC-23731 |
Z57346765
PGK1 inhibitor
|
Z57346765 is a phosphoglycerate kinase 1 (PGK1) inhibitor with Kd of 20.9 uM, significantly reduces the metabolic enzyme activity of PGK1 in glycolysis, inhibits KIRC cell proliferation. |
| PC-23716 |
G3BP1 inhibitor 129
G3BP1/2 inhibitor
|
G3BP1 inhibitor #129 is a small molecule ligand of G3BP1/2 (Ras-GTPase-activating protein SH3 domain-binding protein 1/2), binds with G3BP1 NTF2L domain with SPR KD of 3.7 uM, prevents stress granules (SGs) formation by disrupting G3BP1/caprin1 interaction. |
| PC-23673 |
TD-198946
Runx1 modulator
|
TD-198946 is a small molecule disease-modifying osteoarthritis compound, effectively repairs cartilage by promoting chondrogenic differentiation and halt osteoarthritis (OA) progression, exerts its effect through the regulation of Runx1 expression. |
| PC-23586 |
NB-598
Squalene epoxidase inhibitor
|
NB-598 (NB598) is a potent competitive inhibitor of squalene epoxidase (SQLE, SE, squalene monooxygenase) with IC50 of 4.4 nM (rat SE), inhibits microsomal squalene epoxidase from dog liver and Hep G2 cells with IC50 of 2.0 and 0.75 nM, respectively. |
| PC-23558 |
LZX-2-73
NUPR1 inhibitor
|
LZX-2-73 is a specific and effective NUPR1 inhibitor with Kd of 2.7 uM, inhibits MIA PaCa-2 cell proliferation with IC50 of 10.9 uM. |
| PC-23557 |
AJO14
NUPR1 inhibitor
|
AJO14 is a specific and effective NUPR1 inhibitor with Kd of 4.9 uM. |
| PC-23555 |
R162
GLUD1 inhibitor
|
R162 is a potent, specific inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1) with Ki of 28.6 uM, inhibits cancer cell proliferation and tumor growth. |
| PC-23530 |
LDR102
ROR1 inhibitor
|
LDR102 (ROR1 inhibitor 19h) is a potent, specfic inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with SPR KD of 100 nM, binds the intracellular kinase domain and inhibits ROR1 kinase activity. |
| PC-23529 |
ARI-1
ROR1 inhibitor
|
ARI-1 is a specific inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1), directly targets the frizzled domain with high binding affinity, inhibits EGFR-TKIs-resisted NSCLC with high ROR1 expression. |
| PC-23519 |
Necrocide 1
Necrosis inducer, TRPM4 activator
|
Necrocide 1 (NC1) is a small molecule inducer of tumor necrosis factor (TNF)-independent necrosis, shows antiproliferative activity with IC50 values of 0.48 and 2 nM for MCF-7 and PC3, respectively. |
| PC-23517 |
ATX968
DHX9 inhibitor
|
ATX968 is a potent and selective inhibitor of DHX9 helicase activity with DHX9 unwinding IC50 of 8 nM, SPR Kd value of 1.3 nM. |
| PC-23494 |
Ibetazol
Importin β inhibitor
|
Ibetazol is novel specific small molecule inhibitor of importin β1 (KPNB1)-mediated nuclear import with EC50 of 6.3 uM in phenotypic importin α1 translocation assays , binds to cysteine 585 of importin β1. |
