| Cat. No. |
Product Name |
Information |
| PC-26377 |
NBDHEX
GST inhibitor
|
NBDHEX is a potent glutathione S-transferase (GST) inhibitor, inhibits human glutathione S-transferases GSTA1-1, GSTP1-1 and GSTM2-2 with IC50 of 25 uM, 0.8 uM and <0.01 uM, is cytotoxic toward P-glycoprotein-overexpressing tumor cell lines. |
| PC-26371 |
OXGR1 agonist A-1
OXGR1 agonist
|
OXGR1 agonist A-1 is a potent and selective OXGR1 (Oxoglutarate Receptor 1, GPR99) agonist, activates Gq signaling of OXGR1 with EC50 of 626.5 nM. |
| PC-26353 |
Rexaceract
GCase PAM, GCase activator
|
Rexaceract (GT-02287) is a potent, selective positive allosteric modulator (PAM) of beta-glucocerebrosidase (β-glucocerebrosidase, β-glucosidase, or GCase) with KD of 17-24 uM at pH 7.4, enhances the function of lysosomal GCase. |
| PC-26317 |
VRK-IN-1
VRK1/VRK2 inhibitor
|
VRK-IN-1 is a potent, selective inhibitor of Vaccinia-related kinases 1 and 2 (VRK1 and VRK2) with ITC KD values of 190 nM and 401 nM, IC50 of 150 nM (VRK1). |
| PC-26316 |
VRK1 inhibitor Compound 1
VRK1 inhibitor
|
VRK1 inhibitor Compound 1 (VRK1-IN-1) is a potent, selective and ATP-competitive inhibitor of Vaccinia-related kinase 1 (VRK1) with Ki of 82 nM and IC50 of 154 nM, selective for VRK1 over VRK2. |
| PC-26307 |
JX24120
MAT2B inhibitor
|
JX24120 is a specific inhibitor for methionine adenosyltransferase MAT2B, directly binds to MAT2B with SPR KD of 4.72 uM, inhibits S-adenosylmethionine (SAMe) synthesis. |
| PC-26291 |
UNC11676A
MDA5 inhibitor
|
UNC11676A is a specific small molecule inhibitor of RNA helicase MDA5 with IC50 of 6 uM, >18-fold selective inhibition over LGP2 and DDX1. |
| PC-26266 |
CVN14
CD38 inhibitor
|
CVN14 is a potent, selective, uncompetitive and brain-penetrant CD38 inhibitor with IC50 of 19 nM and 2 nM for human and mouse CD38 respectively. |
| PC-26242 |
E8431
DCSTAMP antagonist
|
E8431 (Z2371498431) is a specific small molecule antagonist of fusogenic protein DCSTAMP, disrupts DCSTAMP-RAP1B interaction and inhibits RAP1-RAC1 signaling-mediated cytoskeletal reorganization required for osteoclast maturation and fusion, demonstrats significant osteoclastogenesis inhibition (IC50=0.7758 μM) without cytotoxic effects on mBMMs. |
| PC-26237 |
HF13141-H5
GGCX inhibitor
|
HF13141-H5 is a potent, selective inhibitor of γ-Glutamyl carboxylase (GGCX) with IC50 of 240 nM-1 uM in cell-based assays, inhibits γ-carboxylation of vitamin K-dependent clotting factors (VKDCFs) and shows anticoagulant effect. |
| PC-26220 |
Thiostrepton
FOXM1 inhibitor, PRX3 inhibitor
|
Thiostrepton is a thiazole antibiotic that selectively inhibits FOXM1, also significantly inhibits ETV4 K97-Khib, thereby promoting ferroptosis and suppressing ICC cell migration, invasion, and lung metastasis, covalently inhibits Peroxiredoxin 3 (PRX3), disrupting redox balance and selectively induces tumor cell death. |
| PC-26205 |
CN-0928
PCBP2 inhibitor
|
CN-0928 is a specific small molecule inhibitor of poly(C)-binding protein 2 (PCBP2), mitigates AD pathology by inhibiting PCBP2 condensation. |
