CN-0928 | PCBP2 inhibitor | Probechem Biochemicals

Chemical Structure : CN-0928

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CN-0928 (CN0928)

货号: PC-26205Not For Human Use, Lab Use Only.

CN-0928 is a specific small molecule inhibitor of poly(C)-binding protein 2 (PCBP2), mitigates AD pathology by inhibiting PCBP2 condensation.

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生物&药学活性

CN-0928 is a specific small molecule inhibitor of poly(C)-binding protein 2 (PCBP2), mitigates AD pathology by inhibiting PCBP2 condensation.
CN-0928 (1-2 uM) significantly reduced PCBP2 protein level, with the concomitant reduction of BACE1 but not APP or ADAM10 protein level.
CN-0928 (1 uM) significantly reduced PCBP2 condensates in SH-SY5Y-mCherry-PCBP2 cells.
CN-0928 significantly reduced protein levels of PCBP2 and BACE1 in the brain in animal model of 5×FAD mice, significantly reduced protein levels of CTFs as well as Aβ40/42 immunofluorescent signals.
CN-0928 binds to integrator complex subunit 1 (INTS1) and regulates PCBP2 transcription and protein level.
PCBP2 is an RNA-binding protein that contains KH domains and specifically binds the cysteine-rich motif, It is involved in cancer and iron metabolism.

物理化学性质&存储条件

分子量	305.40
分子式	C15H19N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-2-morpholinoacetamide

参考文献

1. Wang L, et al. Nat Commun. 2025 Nov 26;16(1):10514.

CN-0928 (CN0928)

生物&药学活性

物理化学性质&存储条件

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CN-0928 (CN0928)

生物&药学活性

物理化学性质&存储条件

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