HF13141-H5

Chemical Structure : HF13141-H5

加入收藏

货号: PC-26237Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

HF13141-H5 is a potent, selective inhibitor of γ-Glutamyl carboxylase (GGCX) with IC50 of 240 nM-1 uM in cell-based assays, inhibits γ-carboxylation of vitamin K-dependent clotting factors (VKDCFs) and shows anticoagulant effect.
HF13141-H5 specifically inhibits GGCX activity without affecting vitamin K epoxide reductase (VKOR) function.
HF13141-H5 inhibited vitamin K epoxidation in a dose dependent manner, completely abolishing epoxidation activity at 20 uM in in vitro vitamin K epoxidation activity assay.
HF13141-H5 competitively inhibits GGCX by occupying the KH2 substrate-binding pocket.
HF13141-H5 mimics the binding of reduced vitamin K.
HF13141-H5 maintained full inhibitory potency against VKOR variants associated with warfarin resistance and demonstrated robust anticoagulant activity in a zebrafish laser-induced endothelial injury model.

物理化学性质&存储条件

分子量	415.45
分子式	C24H21N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1-oxophthalazin-2(1H)-yl)ethyl (4-(benzyloxy)phenyl)carbamate

参考文献

1. Guomin Shen, et al. Blood Adv. 2025 Dec 22:bloodadvances.2025018776.

2. Patent CN113831293 A 2021-12-24.

HF13141-H5

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

HF13141-H5

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.