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首页-小分子抑制剂&激动剂-Others-Other Targets-CVN14
CVN14

Chemical Structure : CVN14

CAS No.: 2925663-26-7

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CVN14 (CVN-14)

货号: PC-26266Not For Human Use, Lab Use Only.

CVN14 is a potent, selective, uncompetitive and brain-penetrant CD38 inhibitor with IC50 of 19 nM and 2 nM for human and mouse CD38 respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CVN14 is a potent, selective, uncompetitive and brain-penetrant CD38 inhibitor with IC50 of 19 nM and 2 nM for human and mouse CD38 respectively.
CVN14 exhibits no significant inhibition of CD157, PARP1, NAMPT or SIRT1 at 30 uM.
CVN14 inhibits cellular CD38 in CHO cells overexpressing recombinant human CD38 using ε-NAD fluorescence with IC50 of 19 nM.
CVN14 binds to hCD38 with SPR KD of 3.6 nM.

物理化学性质&存储条件

分子量 382.39
分子式 C17H21F3N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(1H-imidazol-1-yl)-6-methyl-N-((1r,4r)-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)pyrimidine-4-carboxamide

参考文献

1. Stott AJ, et al. ACS Med Chem Lett. 2026 Jan 29;17(2):259-265.

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