| Cat. No. |
Product Name |
Information |
| PC-26078 |
HCY-NBD
GSTM2 stablizer
|
HCY-NBD is a small molecule stabilizer of Glutathione S-transferase Mu 2 (GSTM2), promotes sulfenylation at Cys174 of GSTM2 and inhibits its K48-linked ubiquitination at this residue, stabilizes GSTM2 protein levels. |
| PC-26076 |
ERX-208
LIPA inhibitor, ERS inducer
|
ERX-208 is a small molecule ERX-41 analog that binds stereospecifically to lysosomal acid lipase A (LIPA), induces endoplasmic reticulum stress (ERS) and apoptosis in a panel of OCa cell lines in vitro (IC50=100 nM). |
| PC-26063 |
Berberrubine chloride
TDP-43 aggregation inhibitor
|
Berberrubine chloride is an orally active metabolite of berberine, alleviates mucosal lesions and inflammation in mouse colitis models, inhibits TDP-43 aggregation and shows anti-inflammatory, anti-tumor, and antiviral activities. |
| PC-26054 |
AGS8-IN-1
AGS8 inhibitor
|
AGS8-IN-1 is a small molecule inhibitor of activator of G-protein signaling 8 (AGS8), effectively inhibits the formation of the AGS8-Gβγ complex, attenuates VEGF-induced phosphorylation of signaling molecules and inhibits tube formation and migration of HUVECs. |
| PC-26013 |
GPR83 agonist CPD1
GPR83 agonist
|
GPR83 agonist CPD1 is a potent, selective small molecule GPR83 agonist with binding IC50 of 10 nM, induces dose-dependent increases in intracellular Ca+2 release in CHO cells expressing mouse GPR83 with EC50 of 74 nM. |
| PC-26012 |
GPR83 antagonist CPD25
GPR83 antagonist
|
GPR83 antagonist CPD25 is a potent, selective GPR83 antagonist with IC50 of 7 nM. |
| PC-26005 |
GS-1291269
Ketohexokinase inhibitor
|
GS-1291269 is a potent, selective and neutral ketohexokinase (KHK) inhibitor, with IC50 of 0.38 and 2.1 nM against KHK-C and KHK-A, respectively. |
| PC-26000 |
Iodomethylcholine
TMA Lyase inhibitor
|
Iodomethylcholine (IMC) is a highly potent non-lethal, irreversible and non-competitive TMA-generating enzyme CutC/D inhibitor with IC50 of 1.2 nM against Proteus mirabilis CutC/D, reduces TMAO levels in vivo. |
| PC-25999 |
Fluoromethylcholine
TMA Lyase inhibitor
|
Fluoromethylcholine (FMC) is a highly potent TMA Lyase inhibitor in Escherichia coli (IC50 = 900 pM against Proteus mirabilis CutC/D) and in a polymicrobial human fecal culture (IC50 = 7.9 nM). |
| PC-25998 |
TMA Lyase inhibitor 7
TMA Lyase inhibitor
|
TMA Lyase inhibitor 7 is a highly potent, selective Trimethylamine (TMA) Lyase inhibitor with IC50 of 0.4 nM, significant reduces circulating trimethylamine oxide (TMAO) levels in vivo. |
| PC-25965 |
ML194
GPR35 antagonist
|
ML194 is a potent, selective GPR35 antagonist with IC50 of 160 nM, has >57-fold selectivity over GPR55 orphan receptor. |
| PC-25962 |
CVN527
GPR6 inverse agonist
|
CVN527 is a potent and selective, brain penetrant GPR6 inverse agonist, fully inhibits GPR6 with EC50 of 39.5 nM and 34 nM for mouse and human GPR6 in functional GPR6 cAMP HTRF cell -based assays. |
