| Cat. No. |
Product Name |
Information |
| PC-27319 |
G2A antagonist 65
GPR132 antagonist
|
G2A antagonist 65 is a potent, selective G protein coupled receptor 132 (GPR132 or G2A) antagonist with IC50 of 0.69 uM, prevents the 9-HODE-mediated sensitization of capsaicin-induced TRPV1 responses in primary sensory neurons. |
| PC-27318 |
G2A antagonist 31
GPR132 antagonist
|
G2A antagonist 31 is a potent, selective G protein coupled receptor 132 (GPR132 or G2A) antagonist with IC50 of 0.33 uM. |
| PC-27317 |
Lysophosphatidylcholines
9008-30-4
|
Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL), induces cell injury, the production of IL-1β and apoptosis, shows proactive effect on sepsis. |
| PC-27301 |
PHB1 inhibitor TD6
Prohibitin 1 inhibitor
|
PHB1 inhibitor TD6 is a highly potent and selective small-molecule inhibitor of Prohibitin 1 (PHB1), exerts potent anti-tumor activities against CRC, effectively suppresses tumor growth and dissemination by disrupting mitochondrial energy metabolism. |
| PC-27300 |
Fluorizoline
Prohibitin binder
|
Fluorizoline is a synthetic molecule that induces apoptosis by selectively targeting prohibitins, directly binds to prohibitin 1 and 2 (PHB1 and PHB2). |
| PC-27289 |
RUN-89
NRF1 activator
|
RUN-89 is a potent, specific activator of transcription factor nuclear factor erythroid 2-related factor 1 (encoded by NFE2L1, NRF1) with EC50 of 3.1 uM. |
| PC-27287 |
Vosoritide
C-type natriuretic peptide analog, NPR2 agonist
|
Vosoritide (BMN-111) is a biologic analogue of C-type natriuretic peptide (CNP) and a potent stimulator of endochondral ossification, acts to restore chondrogenesis through its binding to natriuretic peptide receptor B (NPR-B, NPR2), resulting in the inhibition of downstream signalling pathways of the overactive FGFR3 gene. |
| PC-27278 |
Catestatin TFA
Catecholamine release inhibitor
|
Catestatin TFA is a potent catecholamine release inhibitory peptide with IC50 of 0.2-0.3 uM, acting as a nicotinic cholinergic antagonist, inhibits nicotinic cholinergic-stimulated catecholamine secretion, signal transduction, and desensitization. |
| PC-27277 |
Catestatin
Catecholamine release inhibitor
|
Catestatin is a potent catecholamine release inhibitory peptide with IC50 of 0.2-0.3 uM, acting as a nicotinic cholinergic antagonist, inhibits nicotinic cholinergic-stimulated catecholamine secretion, signal transduction, and desensitization. |
| PC-27255 |
Dihydroberberine
483-15-8
|
Dihydroberberine (dhBBR) is a berberine derivative that inhibit mitochondrial respiratory complex I, improves whole-body insulin sensitivity through increased AMPK activity, exhibits synergistic effects with sunitinib on NSCLC NCI-H460 cells by repressing MAP kinase pathways. |
| PC-27253 |
TBC1D2 inhibitor G2
TBC1D2 inhibitor
|
TBC1D2 inhibitor G2 is a small molecule TBC1 domain family member 2 (TBC1D2) inhibitor with SPR KD of 0.4 uM, and IC50 of 80 nM in HCCLM3 cells, induces selective autophagic cell death. |
| PC-27242 |
Elamipretide acetate
Antioxidant tetrapeptide
|
Elamipretide acetate (SS-31, MTP-131, Bendavia) is a novel cell-permeable antioxidant tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that targets inner mitochondrial membrane and prevents oxidative damage of neuronal cells and other cell types. |
