Fluorizoline

Chemical Structure : Fluorizoline

CAS No.: 1362243-70-6

加入收藏

货号: PC-27300Not For Human Use, Lab Use Only.

Fluorizoline is a synthetic molecule that induces apoptosis by selectively targeting prohibitins, directly binds to prohibitin 1 and 2 (PHB1 and PHB2).

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Fluorizoline is a synthetic molecule that induces apoptosis by selectively targeting prohibitins, directly binds to prohibitin 1 and 2 (PHB1 and PHB2).
Fluorizoline induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation.
Fluorizoline induces mitochondrial fragmentation and cristae disorganization. Fluorizoline increases the production of reactive oxygen species independently of PHBs and apoptosis induction.
Fluorizoline induces the mitochondrial apoptotic pathway in a BAX/BAK-dependent manner.
Fluorizoline modulates the expression of BCL-2 family members by targeting PHBs in MEFs.
Fluorizoline changes mRNA and protein levels of various BCL-2 family members in HeLa cells.

物理化学性质&存储条件

分子量	362.19
分子式	C15H8Cl2F3NS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,5-Bis(4-chlorophenyl)-4,4,5-trifluoro-4,5-dihydrothiazole

参考文献

1. Sánchez-Vera I, et al. Biochem Pharmacol. 2023 Dec;218:115860.

2. Cosialls AM, et al. Biochem Pharmacol. 2020 Oct;180:114198.

3. Moncunill-Massaguer C, et al. Oncotarget. 2015 Dec 8;6(39):41750-65.

4. érez-Perarnau A, et al. Angew Chemie Int Ed. 2014;53:10150–4.

Fluorizoline

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Fluorizoline

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.