| Cat. No. |
Product Name |
Information |
| PC-25516 |
iOXCT1
OXCT1 inhibitor
|
iOXCT1 (D574-0246) is a specific small molecule 3-Oxoacid CoA-transferase 1 (OXCT1) inhibitor, inhibits the dual enzymatic ketolytic and succinyltransferase activities of OXCT1 specifically. |
| PC-25504 |
DF-003
ALPK1 inhibitor
|
DF-003 (DF003) is a potent, selective and ATP-competitive alpha-kinase 1 (ALPK1) inhibitor with IC50 of 1.5 nM and 16 nM for human ALPK1 and ROSAH disease-causing mutant ALPK1[T237M] respectively. |
| PC-25481 |
W1122
SNX3 inhibitor
|
W1122 is a specific small-molecule inhibitor of Sorting nexin 3 (SNX3). |
| PC-25479 |
SF-153
UHM splicing factor inhibitor
|
SF-153 is a small molecule inhibitor of UHM splicing factor RBM39 and SPF45 with IC50 of 45.8 uM for both, targets U2 Auxiliary Factor Homology Motif (UHM) domains, exerts anti-tumor activities in leukemia cell lines. |
| PC-25465 |
Greatwall inhibitor C-604
Greatwall inhibitor
|
Greatwall inhibitor C-604 (UOS-00054604) is a potent, highly selective Greatwall kinase (GWL, MASTL) inhibitor with IC50 of 9 nM in HTRF assays. |
| PC-25458 |
DH20931
CerS2 agonist
|
DH20931 is a first-in-class, potent small-molecule agonist of Ceramide Synthase 2 (CerS2) with activation constant (Kact) of 16.54 nM, exhibits potent, broad-spectrum, and receptor-independent antitumor activity in vitro and in vivo. |
| PC-25450 |
RTI-19318-32
GPR3 agonist
|
RTI-19318-32 is a potent, specific full agonist of G protein-coupled receptor 3 (GPR3) with EC50 of 260 nM and Emax of 90%. |
| PC-25446 |
G4451
GPR31 inhibitor
|
G4451 is a specific small molecule inhibitor of GPR31, inhibits the GPR31-Gαi3 interaction by targeting the GPR31 conformational transition, effectively blocked MASH progression. |
| PC-25445 |
RGX-202
SLC6A8 inhibitor
|
RGX-202 (RGX202, Ompenaclid, β-guanidinoproprionic acid) is an oral small-molecule creatine mimetic inhibitor of creatine transporter SLC6A8, inhibits cellular creatine import and suppresses intracellular phosphocreatine, creatine, and ATP levels, exhibits broad antitumor activity against diverse primary and metastatic CRCs. |
| PC-25443 |
UCB1244283
SV2A modulator
|
UCB1244283 is a selective allosteric modulator of synaptic vesicle protein 2A (SV2A), selective over SV2B and SV2C, enhances brivaracetam (BRV) binding by occupying an allosteric site near the primary binding site, preventing BRV dissociation. |
| PC-25442 |
UCB7361
SV2A modulator
|
UCB7361 is a selective allosteric modulator of synaptic vesicle protein 2A (SV2A). |
| PC-25436 |
TREM2 agonist As48
TREM2 agonist
|
TREM2 agonist As48 is a specific, small-molecule agonist of triggering receptor expressed on myeloid cells 2 (TREM2) with binding KD of 12.48 uM, capable of simultaneously inhibiting ADAM-mediated receptor sheddin, enhances microglial phagocytosis. |
