iOXCT1 (D574-0246)

Chemical Structure : iOXCT1

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货号: PC-25516Not For Human Use, Lab Use Only.

iOXCT1 (D574-0246) is a specific small molecule 3-Oxoacid CoA-transferase 1 (OXCT1) inhibitor, inhibits the dual enzymatic ketolytic and succinyltransferase activities of OXCT1 specifically.

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生物&药学活性

iOXCT1 (D574-0246) is a specific small molecule 3-Oxoacid CoA-transferase 1 (OXCT1) inhibitor, inhibits the dual enzymatic ketolytic and succinyltransferase activities of OXCT1 specifically.
iOXCT1 significantly reduced both substrate-specific (LACTB K284) and global protein succinylation in a dose-dependent way.
iOXCT1 shows cell viability IC50 of 16.49 and 6.6 uM in primary HepG2 and PLC cells respectively.
iOXCT1 (55 mg/kg, i.p.) significantly inhibited tumor growth in OXCT1-overexpressing tumors in xenograft tumors in nude mice using OXCT1-overexpressing HepG2 cells, but not OXCT1-knockout one.

物理化学性质&存储条件

分子量	446.51
分子式	C24H26N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(benzo[d][1,3]dioxol-5-yl)-4-(6-methyl-2-(p-tolylamino)pyrimidin-4-yl)piperazine-1-carboxamide

参考文献

1. Liu R, et al. Bioorg Chem. 2025 Sep 5;165:108964.

iOXCT1 (D574-0246)

生物&药学活性

物理化学性质&存储条件

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iOXCT1 (D574-0246)

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物理化学性质&存储条件

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