| Cat. No. |
Product Name |
Information |
| PC-35333 |
EC359
LIFR inhibitor
|
EC359 (EC-359) is a first-in-class, orally available inhibitor of leukemia inhibitory factor (LIF), blocks LIF-LIFR interaction and binds to LIFR with affinity of 81 nM in SPR assay. |
| PC-35330 |
CCG-222740
MRTF/SRF inhibitor
|
CCG-222740 (CCG222740) is a pharmacological inhibitor of MRTF/SRF signalling, shows greater inhibitory effect on MRTF/SRF target genes than MRTF-A inhibitor CCG-203971, with IC50 of 5 uM in fibroblast-mediated collagen contraction assay. |
| PC-35314 |
S-230
OXE receptor antagonist
|
OXE-R antagonist S-230 is a highly potent antagonist of oxoeicosanoid receptor (OXE receptor) with IC50 of 0.12 nM, inhibits 5-oxo-ETE-induced calcium mobilization in human neutrophils. |
| PC-35313 |
S-C025
OXE receptor antagonist
|
S-C025 is a highly potent antagonist of oxoeicosanoid receptor (OXE receptor, OXE-R) with IC50 of 0.12 nM. |
| PC-35242 |
Z-590
MIF inhibitor
|
Z-590 is a potent inhibitor of macrophage migration inhibitory factor (MIF) tautomerase activity. |
| PC-35241 |
ISO-92
MIF inhibitor
|
ISO-92 is a potent inhibitor of macrophage migration inhibitory factor (MIF) tautomerase activity with IC50 of 0.55 uM. |
| PC-35239 |
TES-1025
ACMSD inhibitor
|
TES-1025 (TES1025) is a potent, selective inhibitor of human ACMSD (α-Amino-β-carboxymuconate-ε-semialdehyde decarboxylase) with IC50 of 13 nM, increases NAD+ levels in cellular systems. |
| PC-35233 |
SAN9812
|
SAN9812 (Carnostatine) is a potent, highly selective, competitive inhibitor of Carnosinase 1 (CN1) activity with Ki of 11 nM. |
| PC-35219 |
AZD5904
MPO inhibitor
|
AZD5904 (AZD-5904) is a potent, selective irreversible, orally bioavailable myeloperoxidase (MPO) inhibitor with IC50 of 140 nM, similar potency in mouse and rat. |
| PC-35212 |
4-CPPC
MIF-2 inhibitor
|
4-CPPC is the first reversible and selective inhibitor of pro-inflammatory protein macrophage migration inhibitory factor-2 (MIF-2) with Ki of 33 uM, 13-fold selectivity for human MIF-2 versus human MIF-1. |
| PC-35205 |
IACS-010759
OXPHOS inhibitor
|
IACS-010759 (IACS010759) is a small molecule inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targets complex I of the mitochondrial electron transport chain. |
| PC-35201 |
LIN28 inhibitor LI71
LIN28 inhibitor
|
LIN28 inhibitor LI71 is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 7 uM, binds the cold shock domain to suppress LIN28's activity against let-7 in leukemia cells and embryonic stem cells. |
