SpiD7

Chemical Structure : SpiD7

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货号: PC-73365Not For Human Use, Lab Use Only.

SpiD7 is a spirocyclic dimer compound that activates the unfolded protein response (UPR), selectively inhibits growth and induce apoptosis of cancer cells.

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生物&药学活性

SpiD7 is a spirocyclic dimer compound that activates the unfolded protein response (UPR), selectively inhibits growth and induce apoptosis of cancer cells.
SpiD7 activates UPR in both normal and cancer cells, and selectively induces apoptosis in cancer cells.
SpiD7 inhibits growth of high-grade serous carcinoma (HGSC) cell lines, reduces clonogenic growth and survival of HGSC cells (IC50<1 uM), activates effector caspases 3/7.

物理化学性质&存储条件

分子量	526.59
分子式	C31H30N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1',1'''-(heptane-1,7-diyl)bis(4-methylene-3,4-dihydro-5H-spiro[furan-2,3'-indoline]-2',5-dione)

参考文献

1. Kour S, et al. J Biol Chem. 2022 Apr 1:101890.

SpiD7

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SpiD7

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