| Cat. No. |
Product Name |
Information |
| PC-25841 |
3-Nitrooxypropanol
MCR inhibitor
|
3-Nitrooxypropanol (Abrucomstat, 3-NOP) is a small molecule inhibitor of methane formation in the rumen, specifically inhibits methyl-coenzyme M reductase (MCR), inhibit methanogenesis, in vitro and in vivo. |
| PC-25820 |
TP-5801
TNK1 inhibitor
|
TP-5801 is a potent, specific inhibitor of Thirty-eight-negative kinase-1 (TNK1) with IC50 of 1.4 nM, inhibits TNK1-transformed cells. |
| PC-25819 |
AP232
U2AF1-UHM inhibitor
|
AP232 is a specific small molecule splicing factor U2AF-UHM inhibitor with IC50 of 7.96 uM, targets the U2 auxiliary homology motif (UHM) of U2AF1, displays 3-24-fold selectivity against other UHM proteins (RBM39-, SPF45-, PUF60-, and U2AF2-UHM). |
| PC-25818 |
DS89092425
PUF60-UHM inhibitor
|
DS89092425 is a small molecule RNA splicing factor PUF60-UHM inhibitor with ITC KD of 83 uM. |
| PC-25817 |
Claudin 5 binder CL5B
CLDN5 binder
|
Claudin 5 binder CL5B is a small molecule binder of Claudin 5 (CLDN5), binds directly to hCLDN5 with KD of 31.7 uM, opens the blood-brain barrier and safely enhances brain drug delivery. |
| PC-25807 |
Ciliogenesis inhibitor Nao-3
Ciliogenesis inhibitor
|
Ciliogenesis inhibitor Nao-3 (Naonedin-3) is specific small-molecule inhibitor of ciliogenesis, represses primary ciliogenesis and induces the death of chemoresistant ciliated stem-like cells. |
| PC-25798 |
YL0441
ΔFOSB inhibitor
|
YL0441 is a highly effective inhibitor of AP1 transcription factor ΔFOSB with IC50 of 13.7 uM and 12.3 uM, disrupts ΔFOSB/JUND and ΔFOSB/ΔFOSB binding to DNA, inhibits AP1-transcription factor-mediated expression of the luciferase reporter gene with IC50 of 0.1 uM. |
| PC-25797 |
JPC0661
ΔFOSB inhibitor
|
JPC0661 is a specific small molecule direct inhibitor of AP1 transcription factor ΔdeltaFOSB (ΔFOSB), inhibits FOSB/JUND and ΔFOSB DNA-binding biochemically with IC50 of 9 uM and 52 uM respectively. |
| PC-25795 |
ASX-173
Asparagine synthetase inhibitor
|
ASX-173 is a selective, cell-penetrable small molecule inhibitor of human asparagine synthetase (ASNS), inhibits L-asparagine production with IC50 of 0.5 uM,, induces the integrated stress response (ISR), and reduces cell growth in HEK-293A cells. |
| PC-25784 |
ML345
IDE inhibitor, NLRP3 inhibitor
|
ML345 is a potent, selective Insulin-degrading enzyme (IDE, Insulysin) with IC50 of 188 nM, targets a specific cysteine residue (Cys819) in IDE, also is a highly potent and selective NLRP3 inhibitor, directly targets tyrosine 381 (Y381) and disrupts its essential interaction with NIMA-related kinase 7 (NEK7). |
| PC-25765 |
TRF1-TIN2 interaction inhibitor 1
TRF1 inhibitor
|
TRF1-TIN2 interaction inhibitor 1 (Compound 40) is a first-in-class inhibitor of the TRF1:TIN2 interaction with IC50 of 67 uM, binds to TRFH domain of TRF1 (TRF1 TRFH) with KD of 29 uM, disrupts shelterin complex assembly. |
| PC-25748 |
PKSI-527
Plasma kallikrein inhibitor, PLK inhibitor
|
PKSI-527 is a highly selective plasma kallikrein inhibitor, suppresses collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system, also is a selective PLK inhibitor. |
