SI-2 (EPH-116) | SRC-3 inhibitor | Probechem Biochemicals

Chemical Structure : SI-2

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SI-2 (EPH-116, EPH116)

货号: PC-70313Not For Human Use, Lab Use Only.

SI-2 (EPH-116) is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2.

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生物&药学活性

SI-2 (EPH-116) is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2.
SI-2 (EPH-116) selectively reduces cellular protein levels of SRC-3, but not that of CARM-1, blocks MDA-MB-468 cell growth with an IC50 value of 3.4 nM, but spares normal cells.
SI-2 (EPH-116) significantly inhibit primary tumor growth and reduce SRC-3 protein levels in a breast cancer mouse model.
SI-2 (EPH-116) is a "first-in-class" compound that targets oncogenic coactivator.

物理化学性质&存储条件

分子量	265.3
分子式	C15H15N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1E)-1-(2-pyridinyl)-ethanone-2-(1-methyl-1H-benzimidazol-2-yl)hydrazone

参考文献

1. Song X, et al. Proc Natl Acad Sci U S A. 2016 May 3;113(18):4970-5.

2. Rohira AD, et al. Cancer Res. 2017 Aug 15;77(16):4293-4304.

SI-2 (EPH-116, EPH116)

生物&药学活性

物理化学性质&存储条件

参考文献

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SI-2 (EPH-116, EPH116)

生物&药学活性

物理化学性质&存储条件

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