XEN 602 | DMT1 inhibitor | Probechem Biochemicals

Chemical Structure : XEN 602

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XEN 602 (XEN602, XEN-602)

货号: PC-61205Not For Human Use, Lab Use Only.

XEN 602 (XEN602) is a potent, specific divalent metal transporter 1 (DMT1) inhibitor that inhibits Mn incorporation in HEK293 cells with IC50 of 0.3 nM.

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生物&药学活性

XEN 602 (XEN602) is a potent, specific divalent metal transporter 1 (DMT1) inhibitor that inhibits Mn incorporation in HEK293 cells with IC50 of 0.3 nM.
XEN 602 decreases p-STAT3 activation, tumor iron accumulation, and tumor cell proliferation.
XEN 602 significantly reduces tumor number and tumor burden, antagonizes the ability of iron to promote tumor growth in CRC mouse model and patient-derived CRC enteroid orthotopic model.
XEN 602 dose-dependently decreases iron absorption in a hyper-absorption mouse model in vivo.

物理化学性质&存储条件

分子量	911.21
分子式	C45H51FN10O2S4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3''-((carbamimidoylthio)methyl)-4-(2-((carbamimidoylthio)methyl)-4-(3-(piperazin-1-yl)propyl)phenoxy)-4''-(2-((carbamimidoylthio)methyl)-4-fluorophenoxy)-[1,1':4',1''-terphenyl]-3-yl)methyl carbamimidothioate

参考文献

1. Xue X, et al. Cell Metab. 2016 Sep 13;24(3):447-61.

2. Cadieux JA, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):90-5.

3. Wolff NA, et al. Sci Rep. 2018 Jan 9;8(1):211.

4. Zhang Z, et al. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5108-13.

XEN 602 (XEN602, XEN-602)

生物&药学活性

物理化学性质&存储条件

参考文献

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XEN 602 (XEN602, XEN-602)

生物&药学活性

物理化学性质&存储条件

参考文献

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