KPT-6566 (KPT6566) | Pin1 inhibitor | Probechem Biochemicals

Chemical Structure : KPT-6566

CAS No.: 881487-77-0

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KPT-6566 (KPT 6566, KPT6566)

货号: PC-61182Not For Human Use, Lab Use Only.

KPT-6566 (KPT6566) is a potent, specific and covalent inhibitor of the prolyl isomerase PIN1 with Ki of 625.2 nM, IC50 of 0.64 uM.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
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100 mg		Get quote

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生物&药学活性

KPT-6566 (KPT6566) is a potent, specific and covalent inhibitor of the prolyl isomerase PIN1 with Ki of 625.2 nM, IC50 of 0.64 uM.
KPT-6566 dispplays no activity against other PPIases, including GFKBP4 and PPIA.
KPT-6566 covalently binds to the catalytic site of PIN1, decreases the expression levels of mut-p53 and NOTCH1 target genes, inhibits colony forming efficiency in MDA-MB-231 cells (IC50=1.2 uM) through specific PIN1 inhibition.
KPT-6566 curbs self-renewal of breast cancer stem cells and promotes degradation of PIN1, elicits cellular responses to oxidative stress and induces DNA damage in a PIN1-dependent manner, induces cell death of cancer cells and reduces metastasis growth in vivo.

物理化学性质&存储条件

分子量	443.532
分子式	C22H21NO5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetic acid, 2-[[4-[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]imino]-1,4-dihydro-1-oxo-2-naphthalenyl]thio]-

参考文献

1. Campaner E, et al. Nat Commun. 2017 Jun 9;8:15772.

KPT-6566 (KPT 6566, KPT6566)

生物&药学活性

物理化学性质&存储条件

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KPT-6566 (KPT 6566, KPT6566)

生物&药学活性

物理化学性质&存储条件

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