CCT 365623 hydrochloride |CAS:2126136-98-7 Probechem Biochemicals

Chemical Structure : CCT 365623 hydrochloride

CAS No.: 2126136-98-7

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CCT 365623 hydrochloride (CCT365623;CCT-365623)

货号: PC-61190Not For Human Use, Lab Use Only.

CCT 365623 (CCT365623) hydrochloride is a potent, orally active small molecule inhibitor of lysyl oxidase (LOX) with IC50 of 0.89 uM.

规格	价格	库存
2 mg	￥3280	In stock
5 mg	￥5480	In stock
10 mg	￥8980	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

CCT 365623 (CCT365623-) hydrochloride is a potent, orally active small molecule inhibitor of lysyl oxidase (LOX) with IC50 of 0.89 uM.
CCT 365623 inhibits LOX actvity in living cell system (MDCK cysts) at 5 uM, reduces EGFR retention at the cell surface, suppresses EGFR and AKT phosphorylation driven by EGF.
CCT 365623 also activates SMAD2 and downregulates MATN2.
CCT 365623 delays the growth of primary and metastatic tumour cells in vivo.

物理化学性质&存储条件

分子量	443.975
分子式	C18H18ClNO4S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5-((5-(methylsulfonyl)-[1,1'-biphenyl]-3-yl)sulfonyl)thiophen-2-yl)methanamine hydrochloride

参考文献

1. Tang H, et al. Nat Commun. 2017 Apr 18;8:14909.

CCT 365623 hydrochloride (CCT365623;CCT-365623)

生物&药学活性

物理化学性质&存储条件

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CCT 365623 hydrochloride (CCT365623;CCT-365623)

生物&药学活性

物理化学性质&存储条件

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