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首页-小分子抑制剂&激动剂-Others-Other Targets-CCT365623 hydrochloride
CCT365623 hydrochloride

Chemical Structure : CCT365623 hydrochloride

CAS No.: 2126136-98-7

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CCT365623 hydrochloride (CCT 365623, CCT-365623)

货号: PC-61190Not For Human Use, Lab Use Only.

CCT365623 (CCT-365623) hydrochloride is a potent, orally active small molecule inhibitor of lysyl oxidase (LOX) with IC50 of 0.89 uM.

规格 价格 库存 数量
5 mg ￥2180 In stock
10 mg ￥3580 In stock
25 mg ￥5580 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CCT365623 (CCT-365623) hydrochloride is a potent, orally active small molecule inhibitor of lysyl oxidase (LOX) with IC50 of 0.89 uM.
CCT365623 inhibits LOX actvity in living cell system (MDCK cysts) at 5 uM, reduces EGFR retention at the cell surface, suppresses EGFR and AKT phosphorylation driven by EGF.
CCT365623 also activates SMAD2 and downregulates MATN2.
CCT365623 delays the growth of primary and metastatic tumour cells in vivo.

物理化学性质&存储条件

分子量 443.975
分子式 C18H18ClNO4S3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(5-((5-(methylsulfonyl)-[1,1'-biphenyl]-3-yl)sulfonyl)thiophen-2-yl)methanamine hydrochloride

参考文献

1. Tang H, et al. Nat Commun. 2017 Apr 18;8:14909.

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