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首页-小分子抑制剂&激动剂-Others-Other Targets-PAT-1251
PAT-1251

Chemical Structure : PAT-1251

CAS No.: 2007885-39-2

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PAT-1251 (Lenumlostat; GB2064; PAT1251)

货号: PC-61128Not For Human Use, Lab Use Only.

Lenumlostat (GB2064, PAT1251) is a potent, selective and orally bioavailable lysyl oxidase-like 2 (LOXL2) inhibitor with IC50 of 0.71 uM in human whole blood assays, with high selectivity over LOX (400-fold) and other amine oxidases.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Lenumlostat (GB2064, PAT1251) is a potent, selective and orally bioavailable lysyl oxidase-like 2 (LOXL2) inhibitor with IC50 of 0.71 uM in human whole blood assays, with high selectivity over LOX (400-fold) and other amine oxidases.
PAT1251 exhibits efficacy in mouse bleomycin lung fibrosis model.

物理化学性质&存储条件

分子量 399.346
分子式 C18H17F4N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3-((4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)((3R,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl)methanone

参考文献

1. Rowbottom MW, et al. J Med Chem. 2017 May 25;60(10):4403-4423.

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