CBR-096-4 |CAS:1776931-05-5 Probechem Biochemicals

Chemical Structure : CBR-096-4

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CBR-096-4 (CBR 096 4)

货号: PC-70281Not For Human Use, Lab Use Only.

CBR-096-4 is a derivative of the antifungal drug itraconazole (ITA) as an inhibitor of MFB cell fate in resident fibroblasts derived from multiple murine and human tissues.

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生物&药学活性

CBR-096-4 is a derivative of the antifungal drug itraconazole (ITA) as an inhibitor of MFB cell fate in resident fibroblasts derived from multiple murine and human tissues.
CBR-096-4 is devoid of antifungal and human cytochrome P450 inhibitory activity with excellent pharmacokinetics, safety, and efficacy in rodent models of lung, liver, and skin fibrosis.

物理化学性质&存储条件

分子量	636.757
分子式	C35H40N8O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(4-(4-(((2R,4S)-2-((2H-1,2,3-triazol-2-yl)methyl)-2-phenyl-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

参考文献

1. Bollong MJ, et al. Proc Natl Acad Sci U S A. 2017 May 2;114(18):4679-4684.

CBR-096-4 (CBR 096 4)

生物&药学活性

物理化学性质&存储条件

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CBR-096-4 (CBR 096 4)

生物&药学活性

物理化学性质&存储条件

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