| Cat. No. |
Product Name |
Information |
| PC-26799 |
XM462
Dihydroceramide desaturase inhibitor
|
XM462 is a small molecule inhibitor of dihydroceramide desaturase (Des1) with IC50 of 8.2 uM and Ki of 2 uM, inhibits sphingolipid synthesis, triggers autophagy and reduces amyloid secretion by neurons. |
| PC-26798 |
Des 1 inhibitor GT11
Des1 inhibitor
|
Des 1 inhibitor GT11 ((1R,2S)-Deoxy-PR280) is a competitive inhibitor of dihydroceramide desaturase with Ki of 6 uM, induces Des1 inhibition in rat liver microsomes with IC50 of 20 uM. |
| PC-26797 |
PR280
Des1 inhibitor
|
PR280 is a potent small molecule inhibitor of dihydroceramide desaturase 1 (Des1) with IC50 of 700 nM. |
| PC-26781 |
C26-Ceramide
121459-09-4
|
C26 Ceramide is a lipid featuring two hydrophobic tails, one saturated and the other unsaturated, can be used in developing lipid nanoparticles or liposomes. |
| PC-26771 |
Kukoamine A
Trypanothione reductase inhibitor
|
Kukoamine A (KuA) is a potent and selective inhibitor of Crithidia fasciculata trypanothione reductase (TR) with Ki of 1.8 uM, with no significant inhibition on human glutathione reductase, possesses antioxidant, anti-inflammatory activities. |
| PC-26770 |
MEDS613
DHODH inhibitor
|
MEDS613 is a potent, selective hDHODH inhibitor with IC50 of 4.1 nM. |
| PC-26766 |
Acetyl-6-formylpterin
MAIT cell inhibitor, MR1 ligand/upregulator
|
Acetyl-6-formylpterin (Ac-6-FP, Acetyl-6-FP) is a small molecule ligand of MHC-related class I-like molecule MR1, markedly stabilizes MR1, potently up-regulates MR1 cell surface expression, and inhibits MAIT cell activation. |
| PC-26765 |
GAA-4OH
DEGS1 inhibitor
|
GAA-4OH is a potent and irreversible inhibitor of dihydroceramide desaturase-1 (DEGS1), covalently blocks the enzyme catalytic cavity, reduces ceramide-to-dihydroceramide ratios and improves steatosis, inflammation, and fibrosis in mouse model of MASLD. |
| PC-26755 |
ELOVL1-IN-2
ELOVL1 inhibitor
|
ELOVL1-IN-2 is a specific ELOVL1 inhibitor with IC50 of 21 μM, inhibits the condensation step of fatty acid elongation and reduces the synthesis of very long-chain fatty acids, including C26:0 VLCFA. |
| PC-26747 |
HNF4α agonist (Z)-19
HNF4α agonist
|
HNF4α agonist (Z)-19 is a small molecule agonist of hepatocyte nuclear factor 4 alpha (HNF4α) with EC50 of 9.2 uM and SPR KD of 4.6 uM. |
| PC-26745 |
TTBK1/2-IN-1
TTBK1/2 inhibitor
|
TTBK1/2-IN-1 (Compound 3) is a potent tau tubulin kinase 1 and 2 (TTBK1 and TTBK2) inhibitor with IC50 of 816 nM and 384 nM nM for TTBK1 and TTBK2, respectively. |
| PC-26743 |
TTBK inhibitor 13
TTBK inhibitor
|
TTBK inhibitor 13 (TTBK1/2 inhibitor) is a potent and cell active tau tubulin kinase 1 and 2 (TTBK1 and TTBK2) inhibitor with IC50 of 3 nM and 2.8 nM for TTBK1 and TTBK2, respectively. |
