TTBK inhibitor 13 | TTBK inhibitor | Probechem Biochemicals

Chemical Structure : TTBK inhibitor 13

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TTBK inhibitor 13 (TTBK1/2 inhibitor)

货号: PC-26743Not For Human Use, Lab Use Only.

TTBK inhibitor 13 (TTBK1/2 inhibitor) is a potent and cell active tau tubulin kinase 1 and 2 (TTBK1 and TTBK2) inhibitor with IC50 of 3 nM and 2.8 nM for TTBK1 and TTBK2, respectively.

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生物&药学活性

TTBK inhibitor 13 (TTBK1/2 inhibitor) is a potent and cell active tau tubulin kinase 1 and 2 (TTBK1 and TTBK2) inhibitor with IC50 of 3 nM and 2.8 nM for TTBK1 and TTBK2, respectively.
TTBK inhibitor 13 exhibits excellent kinome-wide selectivity against K300 panel.
TTBK inhibitor 13 (10 uM) effectively inhibits TTBK2 activity and, in turn, cilia formation in a cellular model of ciliogenesis in RPE1 cells.
TTBK inhibitor 13 is a powerful tool to interrogate TTBK1/2-mediated biology as it relates to ciliogenesis, neurodegenerative diseases, and beyond.

物理化学性质&存储条件

分子量	307.36
分子式	C17H17N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(1-(2-aminopyrimidin-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl)-3-methylpent-1-yn-3-ol

参考文献

1. Flax R, et al. bioRxiv [Preprint]. 2026 Apr 28:2026.04.27.721186.

TTBK inhibitor 13 (TTBK1/2 inhibitor)

生物&药学活性

物理化学性质&存储条件

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TTBK inhibitor 13 (TTBK1/2 inhibitor)

生物&药学活性

物理化学性质&存储条件

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