HNF4α agonist (Z)-19

Chemical Structure : HNF4α agonist (Z)-19

CAS No.: 504433-24-3

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货号: PC-26747Not For Human Use, Lab Use Only.

HNF4α agonist (Z)-19 is a small molecule agonist of hepatocyte nuclear factor 4 alpha (HNF4α) with EC50 of 9.2 uM and SPR KD of 4.6 uM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

HNF4α agonist (Z)-19 is a small molecule agonist of hepatocyte nuclear factor 4 alpha (HNF4α) with EC50 of 9.2 uM and SPR KD of 4.6 uM.
(Z)-19 reduced triglyceride and total cholesterol accumulation with minimal cytotoxicity and exhibited ferroptosis-protective activity in HepG2 cells.
(Z)-19 lowered plasma triglyceride and total cholesterol levels in hyperlipidemia mouse model, indicating encouraging in vivo efficacy.

物理化学性质&存储条件

分子量	275.31
分子式	C17H13N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-3-((1-methyl-1H-indol-3-yl)methylene)-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one

参考文献

1. Wang T, et al. Eur J Med Chem. 2026 Apr 15;314:118864.