| Cat. No. |
Product Name |
Information |
| PC-45513 |
HQ-415
Metal chelator, TDP-43 modulator
|
HQ-415 is a derivative of 8-hydroxyquinoline that has selectivity for rescuing the distinct toxicities caused by the expression of TDP-43 with EC50 of 15 uM, α-synuclein or polyglutamine proteins. |
| PC-42072 |
BAPTA
Mg2+ chelator
|
BAPTA is a cell-permeant, calcium-specific chelator with high selectivity over Mg2+. |
| PC-45623 |
GW4869
nSMase inhibitor
|
GW-4869 (GW4869, GW 4869) is a cell-permeable, potent, specific, non-competitive inhibitor of neutral sphingomyelinase (nSMase) with IC50 of 1 uM. |
| PC-42082 |
TPEN
LIN28 inhibitor
|
TPEN (TPEDA) is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 2.5 uM, also is a specific cell-permeable heavy metal chelator. |
| PC-42281 |
GGTI298
GGTase I inhibitor
|
GGTI298 (GGTI-298) is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively). |
| PC-27348 |
ST029248
Mast cell activator
|
ST029248 is a small molecule mast cell activator (MCA) with 50% degranulation levels (MCD50) of 2.9 uM, promotes de novo synthesis of cytokines and induce the release of eicosanoids from MCs. |
| PC-27347 |
ST026567
Mast cell activator
|
ST026567 is a small molecule mast cell activator (MCA), induces mouse BMMCs degranulation achieving 50% degranulation levels (MCD50) of 24.6 uM, promotes de novo synthesis of cytokines and induce the release of eicosanoids from MCs. |
| PC-27346 |
VAP-1185
Mast cell activator
|
VAP-1185 is a potent small molecule mast cell activator (MCA), induces mouse BMMCs degranulation, promotes a Th1-biased immune response when combined with TLR9 agonist CpG. |
| PC-27345 |
ST101036
Mast cell activator
|
ST101036 is a small molecule mast cell activator (MCA), induces mouse BMMCs degranulation about 91% at 100 uM, and 38% in human LAD2 cells, promotes de novo synthesis of cytokines and induce the release of eicosanoids from mouse MCs. |
| PC-27344 |
OGG1 agonist F01
OGG1 agonist
|
OGG1 agonist F01 is a potent small-molecule agonist with EC50 of 9.1 uM with 8-oxoGua-containing DNA substrate. |
| PC-27343 |
OGG1 agonist F51
OGG1 agonist
|
OGG1 agonist F51 is a potent small-molecule agonist, protects against PQ-induced cytotoxicity in Kasumi-1 cells, binds to catalytic-site rather than allosteric binding. |
| PC-27321 |
C67-47
PGK1 inhibitor
|
C67-47 is a potent and orally efficacious Phosphoglycerate kinase 1 (PGK1) inhibitor, binds strongly to PGK1 with a dissociation constant (Kd) of 63 nM, exhibits potent antiproliferative effects in pancreatic cancer cells. |
