VAP-1185 | Mast cell activator | Probechem Biochemicals

Chemical Structure : VAP-1185

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VAP-1185 (VAP1185)

货号: PC-27346Not For Human Use, Lab Use Only.

VAP-1185 is a potent small molecule mast cell activator (MCA), induces mouse BMMCs degranulation, promotes a Th1-biased immune response when combined with TLR9 agonist CpG.

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生物&药学活性

VAP-1185 is a potent small molecule mast cell activator (MCA), induces mouse BMMCs degranulation, promotes a Th1-biased immune response when combined with TLR9 agonist CpG.
VAP-1185 combined with CpG induces an inflammatory cytokine response in vitro.
VAP-1185 combined with CpG induces additive humoral effects in vivo.
VAP-1185 combined with CpG provides protection in a lethal challenge model.

物理化学性质&存储条件

分子量	364.42
分子式	C19H23F3N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-(4-isopropylphenyl)-2-(3-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine

参考文献

1. Choi HW, et al. SLAS Discov. 2019 Jul;24(6):628-640.

VAP-1185 (VAP1185)

生物&药学活性

物理化学性质&存储条件

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VAP-1185 (VAP1185)

生物&药学活性

物理化学性质&存储条件

参考文献

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