TPEN (TPEDA) | LIN28 inhibitor | Probechem Biochemicals

Chemical Structure : TPEN

CAS No.: 16858-02-9

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TPEN (LIN28 inhibitor TPEN, TPEDA)

货号: PC-42082Not For Human Use, Lab Use Only.

TPEN (TPEDA) is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 2.5 uM, also is a specific cell-permeable heavy metal chelator.

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100 mg	￥780	In stock
250 mg	￥1180	In stock
500 mg	￥1880	In stock
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生物&药学活性

TPEN (TPEDA) is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 2.5 uM, also is a specific cell-permeable heavy metal chelator.
TPEN (TPEDA) completely inhibits LIN28-mediated oligouridylation at 40 uM.
TPEN (TPEDA) targets only the C-terminal zinc-knuckle domain (ZKD) domain of LIN28 and causes drastic structural changes of the zinc knuckles and RNA-binding residues in the ZKD.
TPEN (TPEDA) was previously shown to induce apoptosis by chelating Zn2+ in cells.

物理化学性质&存储条件

分子量	424.5407
分子式	C26H28N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)-

参考文献

1. Shumaker DK, et al. Cell Calcium. 1998 Feb-Mar;23(2-3):151-64.

2. Ahn YH, et al. Exp Neurol. 1998 Nov;154(1):47-56.

3. Makhov P, et al. Cell Death Differ. 2008 Nov;15(11):1745-51.

4. Wang L, et al. Cell Rep. 2018 Jun 5;23(10):3091-3101.

TPEN (LIN28 inhibitor TPEN, TPEDA)

生物&药学活性

物理化学性质&存储条件

参考文献

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TPEN (LIN28 inhibitor TPEN, TPEDA)

生物&药学活性

物理化学性质&存储条件

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