GW4869 |CAS:6823-69-4 Probechem Biochemicals

Chemical Structure : GW4869

CAS No.: 6823-69-4

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GW4869 (GW-4869, GW 4869)

货号: PC-45623Not For Human Use, Lab Use Only.

GW-4869 (GW4869, GW 4869) is a cell-permeable, potent, specific, non-competitive inhibitor of neutral sphingomyelinase (nSMase) with IC50 of 1 uM.

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5 mg	￥1180	In stock
10 mg	￥1780	In stock
25 mg	￥2980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GW4869 (GW-4869, GW 4869) is a cell-permeable, potent, specific, non-competitive inhibitor of neutral sphingomyelinase (nSMase) with IC50 of 1 uM.
GW4869 does not inhibit acid SMase (>150 uM).
GW4869 partially inhibits TNF-induced sphingomyelin (SM) hydrolysis at 10 uM.

物理化学性质&存储条件

分子量	577.5
分子式	C30H28N6O2 · 2HCl
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 0.044 mg/mL (Need ultrasonic and warming)
Chemical Name/SMILES	2-Propenamide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-, hydrochloride (1:2)

参考文献

1. Luberto C, et al. J Biol Chem. 2002 Oct 25;277(43):41128-39.

2. Marchesini N, et al. J Biol Chem. 2003 Apr 18;278(16):13775-83.

3. Airola MV, et al. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5549-E5558.

GW4869 (GW-4869, GW 4869)

生物&药学活性

物理化学性质&存储条件

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GW4869 (GW-4869, GW 4869)

生物&药学活性

物理化学性质&存储条件

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