GGTI298 |CAS:180977-44-0 Probechem Biochemicals

Chemical Structure : GGTI298

CAS No.: 180977-44-0

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GGTI298 (GGTI-298;GGTI 298)

货号: PC-42281Not For Human Use, Lab Use Only.

GGTI298 (GGTI-298) is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively).

规格	价格	库存
1 mg	￥880	In stock
5 mg	￥1580	In stock
10 mg	￥2380	In stock
25 mg	￥3980	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

GGTI298 (GGTI-298) is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively).
GGTI298 induces G0-G1 block and apoptosis in A549 cells.

物理化学性质&存储条件

分子量	479.63422
分子式	C27H33N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Leucine, N-[4-[[(2R)-2-amino-3-mercaptopropyl]amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester

参考文献

1. McGuire TF, et al. J Biol Chem. 1996 Nov 1;271(44):27402-7.

2. Miquel K, et al. Cancer Res. 1997 May 15;57(10):1846-50.

3. Vogt A, et al. J Biol Chem. 1997 Oct 24;272(43):27224-9.

GGTI298 (GGTI-298;GGTI 298)

生物&药学活性

物理化学性质&存储条件

参考文献

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GGTI298 (GGTI-298;GGTI 298)

生物&药学活性

物理化学性质&存储条件

参考文献

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