| Cat. No. |
Product Name |
Information |
| PC-22886 |
CD80 inhibitor 1
CD80 inhibitor
|
CD80 inhibitor 1 is a specific small molecule inhibitor of human CD80 with SPR KD of 125 nM, antagonize CD28 (TR_FRET EC50=630 nM) and CTLA-4 binding to CD80, inhibits the release of the proinflammatory cytokines IL-2, IFNγ, and TNFα at submicromolar doses in T cell costimulation assays. |
| PC-22881 |
DPTIP
nSMase 2 inhibitor
|
DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor with IC50 of 30 nM. |
| PC-22870 |
12-deoxyphorbol 13-palmitate
APOL2 inhibitor
|
12-deoxyphorbol 13-palmitate is a potent inhibitor of hepatic stellate cell (HSC) activation, directly and specifically targets apolipoprotein L2 (APOL2). |
| PC-22844 |
LXG6403
LOX inhibitor
|
LXG6403 is a highly potent, irreversible lysyl oxidase (LOX) inhibitor, inhibits cellular LOX activity efficiently in MDA-MB-231 cells with IC50 of 1.3 uM, >3-fold selective over LOXL2 and no activity against LOXL1. |
| PC-22842 |
SD-066-4
ZDHHC20 inhibitor
|
SD-066-4 is a selective inhibitor of S-acyltransferase ZDHHC20 (Zinc Finger DHHC-Type Palmitoyltransferase 20), inhibits EGFR S-acylation at concentrations as low as 1 uM. |
| PC-22812 |
EHD4 inhibitor MS1
EHD4 inhibitor
|
EHD4 inhibitor MS1 is a small molecule inhibitor of Eps15 Homology Domain Protein 4 (EHD4) with IC50 of 0.92 uM, inhibits Eps15 EHD4's liposome-stimulated ATPase activity. |
| PC-22766 |
Pertussis Toxin
Gi protein inhibitor
|
Pertussis Toxin is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, inhibits G protein-coupled receptor (GPR) signaling through Gi proteins. |
| PC-22760 |
AS1411
Nucleolin inhibitor
|
AS1411 is a quadruplex-forming oligonucleotide aptamer that targets nucleolin, inhibits cancer cell proliferation. |
| PC-22755 |
GCS-12
NKT cell agonist
|
GCS-12 is a highly potent αGalCer sulfonamide analogue as natural killer T (NKT) cell agonist, enhances interaction of the glycolipid/CD1d complex, exhibits selectivity for the induction of IFN-γ over IL-4, shows potent antitumor activities. |
| PC-22754 |
GCS-11
NKT cell agonist
|
GCS-11 is a highly potent αGalCer sulfonamide analogue as natural killer T (NKT) cell agonist, enhances interaction of the glycolipid/CD1d complex, exhibits selectivity for the induction of IFN-γ over IL-4, shows potent antitumor activities. |
| PC-22713 |
Bongkrekic acid
Mitochondrial toxin
|
Bongkrekic acid is a specific small molecule inhibitor of the adenine nucleotide translocase of mitochondria and mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans, inhibits ADP/ATP transport. |
| PC-22695 |
LH1753
L-cystine crystallization inhibitor
|
LH1753 is an orally bioavailable inhibitor of L-cystine crystallization for cystinuria, prevents stone formation effectively in the Slc3a1-knockout mouse model. |
