| Cat. No. |
Product Name |
Information |
| PC-25504 |
DF-003
ALPK1 inhibitor
|
DF-003 (DF003) is a potent, selective and ATP-competitive alpha-kinase 1 (ALPK1) inhibitor with IC50 of 1.5 nM and 16 nM for human ALPK1 and ROSAH disease-causing mutant ALPK1[T237M] respectively. |
| PC-25481 |
W1122
SNX3 inhibitor
|
W1122 is a specific small-molecule inhibitor of Sorting nexin 3 (SNX3). |
| PC-25479 |
SF-153
UHM splicing factor inhibitor
|
SF-153 is a small molecule inhibitor of UHM splicing factor RBM39 and SPF45 with IC50 of 45.8 uM for both, targets U2 Auxiliary Factor Homology Motif (UHM) domains, exerts anti-tumor activities in leukemia cell lines. |
| PC-25465 |
Greatwall inhibitor C-604
Greatwall inhibitor
|
Greatwall inhibitor C-604 (UOS-00054604) is a potent, highly selective Greatwall kinase (GWL, MASTL) inhibitor with IC50 of 9 nM in HTRF assays. |
| PC-25458 |
DH20931
CerS2 agonist
|
DH20931 is a first-in-class, potent small-molecule agonist of Ceramide Synthase 2 (CerS2) with activation constant (Kact) of 16.54 nM, exhibits potent, broad-spectrum, and receptor-independent antitumor activity in vitro and in vivo. |
| PC-25446 |
G4451
GPR31 inhibitor
|
G4451 is a specific small molecule inhibitor of GPR31, inhibits the GPR31-Gαi3 interaction by targeting the GPR31 conformational transition, effectively blocked MASH progression. |
| PC-25445 |
RGX-202
SLC6A8 inhibitor
|
RGX-202 (RGX202, Ompenaclid, β-guanidinoproprionic acid) is an oral small-molecule creatine mimetic inhibitor of creatine transporter SLC6A8, inhibits cellular creatine import and suppresses intracellular phosphocreatine, creatine, and ATP levels, exhibits broad antitumor activity against diverse primary and metastatic CRCs. |
| PC-25339 |
CQ3196
RIOK2 inhibitor
|
CQ3196 is a potent and orally bioavailable RIO kinase 2 (RIOK2) inhibitor with binding Kd of 14 nM, suppresses RIOK2 ATPase activity in vitro with IC50 of 72 nM in an ADP-Glo kinase assays. |
| PC-25281 |
KI-DX-014
DDX21 inhibitor
|
KI-DX-014 is a specific small-molecule compound capable of inhibiting the interaction of DDX21 with RNA with IC50 of 3.31 uM, directly binds to DDX21-C-terminal domain (HC+CTD) with Kd of 15.9 uM, allosterically attenuates DDX21 ATPase activity. |
| PC-25222 |
ASS1 inhibitor C-01
ASS1 inhibitor
|
ASS1 inhibitor C-01 is a small molecule inhibitor of argininosuccinate synthetase 1 (ASS1), binds to ASS1 directly with SPR Kd of 18.8 nM. |
| PC-25184 |
JX-078
LAT1 inhibitor
|
JX-078 is a potent, selective inhibitor of L-type amino acid transporters LAT1 (SLC7A5), inhibits [3H]-L-leucine uptake into HT-29 cells with IC50 of 121 nM, >10-fold selective over in LAT2. |
| PC-25146 |
BI033
BACH1 inhibitor
|
BI033 is a selective small-molecule BTB and CNC homology 1 (BACH1) inhibitor, specifically binds to BACH1 WT with Kd of 9.0 uM, significantly upregulates HO-1 mRNA and protein expression. |
