| Cat. No. |
Product Name |
Information |
| PC-25426 |
ARN398
Acid ceramidase inhibitor
|
ARN398 is a higly potent, selective inhibitor of acid ceramidase (ACDase, ASAH1) with IC50 of 7 nM and 12 nM for human and rat ACDase respectively, >100-fold selective over human thymidylate synthase (h-TS). |
| PC-25425 |
ARN14988
Acid ceramidase inhibitor
|
ARN14988 is a potent, selective inhibitor of acid ceramidase (ACDase, ASAH1) with IC50 of 12.8 nM. |
| PC-25424 |
Pepstatin A
Aspartic protease inhibitor
|
Pepstatin A (Pepstatin) is a potent, specific, orally active aspartic protease inhibitor with IC50 of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. |
| PC-25387 |
5-O-Methylvisammioside
HMGB1 inhibitor, CNT2 inhibitor
|
5-O-Methylvisammioside (5OMV) is a flavonol compound derived from the traditional Chinese medicine plant Saposhnikovia divaricat, inhibits vasospasm induced by High Mobility Group Box 1 (HMGB1) protein, also inhibits intestinal concentrative nucleoside transporter 2 (CNT2) with IC50 of 11.22 uM, inhibits intestinal purine nucleoside absorption. |
| PC-25384 |
Acid ceramidase inhibitor 43
Acid ceramidase inhibitor
|
Acid ceramidase inhibitor 43 is a potent, small molecule inhibitor of acid ceramidase (aCDase) with enzymatic pIC50 of 8.5 and cellular pIC50 of 6.8 (A375 melanoma cell). |
| PC-25357 |
Avicularin
FOXM1 inhibitor
|
Avicularin is a Chinese herbal medicine with anti-inflammatory and antioxidative effects, reduces cell viability and induces caspase-dependent apoptosis in NSCLC cells by facilitating USP7-dependent degradation of FOXM1. |
| PC-25349 |
hClpP inhibitor TG42
hClpP inhibitor
|
hClpP inhibitor TG42 is a potent and selective inhibitor of hClpP with IC50 of 0.39 uM, efficiently blocks proteolysis. |
| PC-25347 |
BC8a
hClpP inhibitor
|
BC8a (ClpP inhibitor 8a) is a potent inhibitor of hClpP with IC50 of 10.2 uM, inhibits hClpP peptidase activity, also inhibits the holoenzyme hClpXP. |
| PC-25340 |
Imifoplatin
CAS 1339960-28-9
|
Imifoplatin (PT-112) is the first pyrophosphate-platinum conjugate, causes immunogenic cell death in experimental models, is an immunogenic cell death (ICD)-inducing small molecule, inhibits ribosome biogenesis and causes organelle stresses, leading to selective ICD in cancer cells. |
| PC-25330 |
Dioctatin
ClpP activator
|
Dioctatin is a small molecule inhibitor of aflatoxin production of Aspergillus flavus, binds to and activates mitochondrial protease ClpP of A. flavus and Escherichia coli. |
| PC-25317 |
PRDX1 inhibitor CP1
PRDX1 inhibitor
|
PRDX1 inhibitor CP1 is a potent, high-affinity small molecule peroxiredoxin 1 (PRDX1) inhibitor with IC50 of 0.08 nM and MST binding Kd of 0.06 nM. |
| PC-25316 |
Conoidin A
PRDX1 inhibitor, TgPrxII inhibitor
|
Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties, covalently binds to the peroxidatic Cys47 of TgPrxII and inhibits its hyperperoxidation activity with IC50 of 23 uM, also is a small molecule peroxiredoxin 1 (PRDX1) inhibitor with IC50 of 14.8 uM. |
