IDE inhibitor Ii1 | IDE inhibitor | Probechem Biochemicals

Chemical Structure : IDE inhibitor Ii1

加入收藏

IDE inhibitor Ii1 (IDE inhibitor 1)

货号: PC-26433Not For Human Use, Lab Use Only.

IDE inhibitor Ii1 (IDE inhibitor 1) is a potent, selective inhibitor of insulin degrading enzyme (IDE) with Ki of 1.7 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

IDE inhibitor Ii1 (IDE inhibitor 1) is a potent, selective inhibitor of insulin degrading enzyme (IDE) with Ki of 1.7 nM.
Ii1 exhibits a purely competitive mode of inhibition of the hydrolysis of insulin and Aβ.
Ii1 shows remarkably selective for IDE versus a wide range of conventional zinc-metalloproteases and representative members of other protease classes.
Ii1 inhibits the degradation of extracellular insulin dose-dependently, with IC50 of ~10 nM, in CHO cells overexpressing the human insulin receptor (IR).

物理化学性质&存储条件

分子量	743.82
分子式	C37H45N9O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-amino-4-((S)-2-((S)-5-guanidino-2-((R)-4-(hydroxyamino)-2-(naphthalen-2-ylmethyl)-4-oxobutanamido)pentanamido)-3-(1H-indol-3-yl)propanamido)-5-oxopentanoic acid

参考文献

1. Malcolm A Leissring, et al. PLoS One. 2010 May 7;5(5):e10504.

2. Takeshi Shiiki, et al. Biol Pharm Bull. 2025;48(11):1700-1707.

IDE inhibitor Ii1 (IDE inhibitor 1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

IDE inhibitor Ii1 (IDE inhibitor 1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.