| Cat. No. |
Product Name |
Information |
| PC-26086 |
IDB-003
Translation inhibitor
|
IDB-003 is an orally active, unique context-dependent inhibitor of human translation that bind to the ribosome peptidyl transferase center (PTC) and inhibits elongation. |
| PC-26085 |
IDB-001
Translation inhibitor
|
IDB-001 is a small molecule, unique context-dependent inhibitor of human translation that bind to the ribosome peptidyl transferase center (PTC) and inhibits elongation. |
| PC-26079 |
TREM2 agonist S9
TREM2 agonist
|
TREM2 agonist S9 is a potent, small molecule Triggering receptor expressed on myeloid cells-2 (TREM2) agonist with MST binding KD of 0.95 uM. |
| PC-26078 |
HCY-NBD
GSTM2 stablizer
|
HCY-NBD is a small molecule stabilizer of Glutathione S-transferase Mu 2 (GSTM2), promotes sulfenylation at Cys174 of GSTM2 and inhibits its K48-linked ubiquitination at this residue, stabilizes GSTM2 protein levels. |
| PC-26076 |
ERX-208
LIPA inhibitor, ERS inducer
|
ERX-208 is a small molecule ERX-41 analog that binds stereospecifically to lysosomal acid lipase A (LIPA), induces endoplasmic reticulum stress (ERS) and apoptosis in a panel of OCa cell lines in vitro (IC50=100 nM). |
| PC-26063 |
Berberrubine chloride
TDP-43 aggregation inhibitor
|
Berberrubine chloride is an orally active metabolite of berberine, alleviates mucosal lesions and inflammation in mouse colitis models, inhibits TDP-43 aggregation and shows anti-inflammatory, anti-tumor, and antiviral activities. |
| PC-26054 |
AGS8-IN-1
AGS8 inhibitor
|
AGS8-IN-1 is a small molecule inhibitor of activator of G-protein signaling 8 (AGS8), effectively inhibits the formation of the AGS8-Gβγ complex, attenuates VEGF-induced phosphorylation of signaling molecules and inhibits tube formation and migration of HUVECs. |
| PC-26035 |
SecA activator HSI#6
SecA activator
|
SecA activator HSI#6 is a small molecule, specific and allosteric activator of SecA dependent secretion, binds onto SecA and allosterically activates the translocase with AC50 of 3.76 uM, activates the soluble, membrane-bound and at-translocation-site SecA states. |
| PC-26024 |
BPU17
Prohibitin inhibitor
|
BPU17 is a specific small molecule inhibitor of prohibitin, binds to prohibitin 1 (PHB1) and inhibits the PHB1-PHB2 interaction, inhibits epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells (RPEs) and exhibits antifibrotic activity in vivo. |
| PC-26013 |
GPR83 agonist CPD1
GPR83 agonist
|
GPR83 agonist CPD1 is a potent, selective small molecule GPR83 agonist with binding IC50 of 10 nM, induces dose-dependent increases in intracellular Ca+2 release in CHO cells expressing mouse GPR83 with EC50 of 74 nM. |
| PC-26012 |
GPR83 antagonist CPD25
GPR83 antagonist
|
GPR83 antagonist CPD25 is a potent, selective GPR83 antagonist with IC50 of 7 nM. |
| PC-26005 |
GS-1291269
Ketohexokinase inhibitor
|
GS-1291269 is a potent, selective and neutral ketohexokinase (KHK) inhibitor, with IC50 of 0.38 and 2.1 nM against KHK-C and KHK-A, respectively. |
