| Cat. No. |
Product Name |
Information |
| PC-62585 |
TRAF-STOP 6860766
CD40-TRAF6 inhibitor
|
TRAF-STOP 6860766 (SMI-6860766, SMI6860766) is a small molecule inhibitor that blocks the interaction between CD40 and TRAF6 (TRAF-STOP), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity. |
| PC-62579 |
N-acetyl lysyltyrosylcysteine amide
MPO inhibitor
|
N-acetyl lysyltyrosylcysteine amide (KYC) is a potent, tripeptide inhibitor of myeloperoxidase (MPO), inhibits MPO-mediated hypochlorous acid (HOCl) formation (IC50=7 uM) and nitration/oxidation of LDL. |
| PC-62577 |
Visomitin
Antioxidant
|
Visomitin (SKQ1 bromide, PDTP) is a mitochondria-targeted antioxidant that decreases transmembrane potential and production of reactive oxygen species (ROS). |
| PC-62535 |
SPL-707
SPPL2a inhibitor
|
SPL-707 (SPL707) is the first selective, orally active signal peptide peptidase-like 2a (SPPL2a) inhibitor with IC50 of 77 nM, shows 25-fold selectivity over γ-secretase and SPP. |
| PC-62489 |
GAPDS
GAPDH inhibitor, GAPDH segregator
|
GAPDS is a small molecule that targets the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH). |
| PC-62473 |
GGTI-286 hydrochloride
GGTase I inhibitor
|
GGTI-286 hydrochloride is a CAAX peptidomimetic that is a potent, cell-permeable, and selective inhibitor of GGTase I with IC50 of 2 uM, 25-fold more potent than FTI-277. |
| PC-62472 |
GGTI-286
GGTase I inhibitor
|
GGTI-286 is a CAAX peptidomimetic, potent, cell-permeable, and selective inhibitor of GGTase I with IC50 of 2 uM, 25-fold more potent than FTI-277. |
| PC-62471 |
GGTI-2147
GGTase I inhibitor
|
GGTI-2147 is a non-thiol peptidomimetic that inhibits GGTase I and blocks geranyl-geranylation of Rap1A (IC50=0.5 uM). |
| PC-62470 |
GGTI-2133
GGTase I inhibitor
|
GGTI-2133 is a cell-permeable, non-thiol peptidomimetic that acts as a potent and selective inhibitor of GGTase I (IC50=38 nM), displays 40-fold selectivity over FTase. |
| PC-62437 |
CSIC E379
UCP1/UCP2 inhibitor
|
CSIC E379 is a potent, selective uncoupling proteins UCP1/UCP2 inhibitor with EC50 of 20 uM/30 uM, respectively. |
| PC-62435 |
Cytochalasin B
Actin inhibitor, GLUT inhibitor
|
Cytochalasin B is a cell-permeable mycotoxin that inhibits network formation by actin filaments, inhibits cell movement and induces nuclear extrusion, shows Kd value of 1.4-2.2 nM for F-actin. |
| PC-62434 |
Antimycin A
Cytochrome c reductase inhibitor
|
Antimycin A is an inhibitor of cellular respiration, specifically oxidative phosphorylation, binds to the Qi site of cytochrome c reductase, disrupts the Q-cycle of enzyme turn over. |
