GGTI-2133 |CAS:191102-79-1 Probechem Biochemicals

Chemical Structure : GGTI-2133

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GGTI-2133 (GGTI2133)

货号: PC-62470Not For Human Use, Lab Use Only.

GGTI-2133 is a cell-permeable, non-thiol peptidomimetic that acts as a potent and selective inhibitor of GGTase I (IC50=38 nM), displays 40-fold selectivity over FTase.

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生物&药学活性

GGTI-2133 is a cell-permeable, non-thiol peptidomimetic that acts as a potent and selective inhibitor of GGTase I (IC50=38 nM), displays 40-fold selectivity over FTase.
GGTI-2133 increases deformability and impairs low O2 tension-induced ATP release in healthy human erythrocytes.
GGTI-2133 inhibits antigen-induced BSM hyperresponsiveness, probably by reducing downstream signal transduction of RhoA.

物理化学性质&存储条件

分子量	570.56
分子式	C27H28N4O3 · C2HF3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Leucine, N-[4-[(1H-imidazol-4-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]- (9CI)

参考文献

1. Vasudevan A, et al. J Med Chem. 1999 Apr 22;42(8):1333-40.

2. Clapp KM, et al. Am J Physiol Heart Circ Physiol. 2013 Mar 1;304(5):H660-6.

3. Chiba Y, et al. Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L984-91.

GGTI-2133 (GGTI2133)

生物&药学活性

物理化学性质&存储条件

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GGTI-2133 (GGTI2133)

生物&药学活性

物理化学性质&存储条件

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