GGTI-2147 |CAS:191102-87-1 Probechem Biochemicals

Chemical Structure : GGTI-2147

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GGTI-2147 (GGTI2147)

货号: PC-62471Not For Human Use, Lab Use Only.

GGTI-2147 is a non-thiol peptidomimetic that inhibits GGTase I and blocks geranyl-geranylation of Rap1A (IC50=0.5 uM).

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生物&药学活性

GGTI-2147 is a non-thiol peptidomimetic that inhibits GGTase I and blocks geranyl-geranylation of Rap1A (IC50=0.5 uM).
GGTI-2147 inhibits glucose- and KCl-induced insulin secretion.
GGTI-2147 inhibits Rac1 geranylgeranylation, down-regulates the expression of p65, and ameliorated the OGD/R-induced neuronal apoptosis.

物理化学性质&存储条件

分子量	470.6
分子式	C28H30N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Leucine, N-[4-[(1H-imidazol-4-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester (9CI)

参考文献

1. Vasudevan A, et al. J Med Chem. 1999 Apr 22;42(8):1333-40.

2. Amin R, et al. J Pharmacol Exp Ther. 2002 Oct;303(1):82-8.

3. Gao S, et al. Neuropharmacology. 2016 Apr;103:44-56.

GGTI-2147 (GGTI2147)

生物&药学活性

物理化学性质&存储条件

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GGTI-2147 (GGTI2147)

生物&药学活性

物理化学性质&存储条件

参考文献

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