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首页-小分子抑制剂&激动剂-Others-Other Targets-CSIC E379
CSIC E379

Chemical Structure : CSIC E379

CAS No.: 1220476-13-0

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CSIC E379

货号: PC-62437Not For Human Use, Lab Use Only.

CSIC E379 is a potent, selective uncoupling proteins UCP1/UCP2 inhibitor with EC50 of 20 uM/30 uM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CSIC E379 is a potent, selective uncoupling proteins UCP1/UCP2 inhibitor with EC50 of 20 uM/30 uM, respectively.
    CSIC E379 does not affect OXPHOS system and membrane permeability in liver mitochondria.
    CSIC E379 causes oxidative stress, inhibit the cellular respiration of the cancer cell line HT-29.
    CSIC E379 increases the production of superoxide and decreases the cell viability.
    CSIC E379 potentiates the efficacy of the cytotoxic drug arsenic trioxide.

    物理化学性质&存储条件

    分子量 280.411
    分子式 C20H24O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    8-isopropyl-2,2-dimethyl-6-phenylchromane

    参考文献

    1. Rial E, et al. Chem Biol. 2011 Feb 25;18(2):264-74.

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